Publications by authors named "Arazu Sharif"
Neurodegenerative disorders present complex pathologies characterized by various interconnected factors, including the aggregation of misfolded proteins, oxidative stress, neuroinflammation and compromised blood-brain barrier (BBB) integrity. Addressing such multifaceted pathways necessitates the development of multi-target therapeutic strategies. Emerging research indicates that probucol, a historic lipid-lowering medication, offers substantial potential in the realm of neurodegenerative disease prevention and treatment.
View Article and Find Full Text PDFArticle Synopsis
- There is a growing link between type 2 diabetes and Alzheimer's disease, highlighting issues like brain insulin resistance and the presence of toxic amyloid-β proteins.
- Recent findings suggest that amyloid-β is released from fat-storing organs as lipid-rich particles, which can damage the blood-brain barrier and lead to inflammation and cognitive decline.
- The study proposes that the relationship between diabetes and Alzheimer's may stem from high levels of these lipid particles affecting brain health, and it discusses potential treatments that target related metabolic disorders.
Endometriosis is a complex and potentially debilitating condition that has major impact on quality of life. There is emerging evidence that biological compounds found in garlic () may be effective for attenuating endometrial pain. Suggested mechanisms for efficacy include modulation of inflammation and potent antioxidant effects.
View Article and Find Full Text PDFCirculatory disturbance of the cochlear spiral modiolar artery in a type 2 diabetic mouse model.
Laryngoscope Investig Otolaryngol
October 2022
Objective: This study aimed to identify significant differences in cochlea microvessel size between a diabetic mouse model (db/db) and normal mice using three-dimensional (3D) quantitative analysis.
Methods: Six control heterozygote db/+ as well as 18 male B6/BKS(D)-Lepr/J (db/db) mice aged 14 ( = 9) and 28 ( = 9) weeks were examined. After clearing the cochlea, we reconstructed the 3D volumes of the spiral modiolar artery (SMA) in the cochlea using light-sheet microscopy and analyzed vessel wall thickness, cross-sectional area, short and long diameter, and vessel height.