Hepatic Toxicity in Etroplus suratensis (Bloch 1790): An Economically Important Edible Fish in Vembanad Fresh Water Lake, Kerala, India.

Fish consumption from contaminated water-bodies is a serious health issue. This study conducted to reveal the presence of heavy metals and bisphenols in Vembanad lake, an exploiting tourist spot in Kerala, receiving untreated agricultural, domestic, municipal, and industrial effluents. We evaluated aquatic contaminant impact on hepatic stress markers in Etroplus suratensis from fragile Vembanad lake.

L-Ascorbic Acid and α-Tocopherol Reduces Hepatotoxicity Associated with Arsenic Trioxide Chemotherapy by Modulating Nrf2 and Bcl2 Transcription Factors in Chang liver Cells.

Arsenic trioxide (AsO) is a promising new regimen for the treatment of acute promyelocytic leukemia (APL). The induction of oxidative stress mediated by reactive oxygen species (ROS) and excessive intracellular calcium influx are the main reasons behind AsO toxicity. Since liver is the major organ for xenobiotic metabolism, it is always under stress.

L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes by the activation of Nrf2 and Bcl2 transcription factors.

Arsenic trioxide (AsO) is a potent drug for the treatment of acute promyelocytic leukemia (APL) and has achieved remarkable remissions in patients. Unfortunately, clinical reports have shown that the treatment is associated with cardiotoxicity. Many efforts have been made to mitigate drug-mediated cardiac damage using naturally occurring antioxidant compounds possessing free radical scavenging activity.