Publications by authors named "Aratari A"
Objectives: Elderly hospitalized patients with inflammatory bowel disease (IBD) flare and concurrent Clostridioides difficile infection (CDI) are considered at high risk of IBD-related complications. We aimed to evaluate the short, intermediate, and long-term post-discharge complications among these patients.
Methods: A retrospective multicenter cohort study assessing outcomes of elderly individuals (≥60 years) hospitalized for an IBD flare who were tested for CDI (either positive or negative) and discharged.
Background: Few data are available addressing the impact of post-operative management of Crohn's disease (CD) on long-term clinical course.
Aim: To assess the evolution of post-operative management strategies over the last 40 years and their impact on the re-operation rate of CD.
Methods: We included 657 patients with CD who had undergone their first radical ileo-caecal resection between 1980 and 2020.
Background/aims: Endoscopic stenting for stricturing Crohn's disease (CD) is an emerging treatment that achieves more persistent dilatation of the stricture over time than endoscopic balloon dilatation (EBD). We aimed to explore the efficacy and safety of stenting for the treatment of CD strictures.
Methods: A systematic electronic literature search was performed (PROSPERO; no.
Background: The administration of biological drugs in inflammatory bowel diseases (IBD) is increasingly moving from intravenous to subcutaneous formulations.
Aims: To evaluate the efficacy and safety of vedolizumab subcutaneous administration after switching from intravenous administration in ulcerative colitis (UC) patients in corticosteroid-free clinical remission.
Methods: An observational, multicentre, prospective study was conducted by the Italian Group for the study of IBD (IG-IBD).
Article Synopsis
- The study examines the management of postoperative recurrence (POR) in Crohn's disease (CD) patients after surgery, focusing on whether early immunosuppression is necessary for those with just one risk factor.
- The research involved comparing two groups: one receiving immediate immunosuppression after surgery and another guided by endoscopy, measuring endoscopic and clinical recurrence rates.
- Results showed no significant differences in recurrence rates between the two groups, indicating immediate immunoprophylaxis may not be beneficial, suggesting the need for further prospective studies.
Article Synopsis
- - This study analyzed cases of solid organ transplantation in patients with inflammatory bowel diseases (IBD), focusing on changes in therapy and health outcomes related to IBD before and after transplantation.
- - The research included 34 transplantations across 33 patients, mostly suffering from Crohn's disease, with most patients treated with immunosuppressive medications post-surgery.
- - Results indicated that the severity of IBD remained stable after transplantation, but an increase in cancer cases was observed, highlighting the need for further research on cancer risk in these patients.
Inflammatory bowel diseases (IBD) are chronic, progressive and relapsing inflammatory disorders of unknown etiology that may cause disability over time. Data from epidemiologic studies indicate that diet may play a role in the risk of developing and the course of IBD. It is known that the group of beneficial bacteria was reduced in the IBD and that the Mediterranean diet (MD)-which is defined as eating habits characterized by high consumption of plant foods, mainly cereals, vegetables, fruit as well as olive oil, and small portions of dairy products, sweets, sugar and meat products-affects gut microbiota, enriching beneficial bacteria, which support gut barrier function and reduce inflammation.
View Article and Find Full Text PDFBackground & Aims: Colonoscopy (CS) is the gold standard to assess postoperative recurrence (POR) in Crohn's disease (CD). However, CS is invasive and may be poorly tolerated by patients. The aim of this study was to prospectively assess the diagnostic accuracy of a noninvasive approach in detecting POR, using the endoscopic Rutgeerts' score (RS) as the reference standard.
View Article and Find Full Text PDFArticle Synopsis
- The study compared the effectiveness of ustekinumab and vedolizumab as second-line treatments for Crohn's disease in patients who did not respond to TNF inhibitors, with outcomes assessed through clinical measures and imaging techniques.
- Results showed no significant differences in clinical outcomes at 26 weeks, but at 52 weeks, vedolizumab performed better with higher rates of clinical remission (55.5% vs 42.5%) and steroid-free remission (51.1% vs 40.6%).
- Both treatments had similar safety profiles, and clinical responses at 26 weeks were predictive of later steroid-free remission for both medications.
Background: The effectiveness of ustekinumab in patients with refractory Crohn's disease (CD) has been investigated in several real-world studies. However, very few data concerning the real-life experience in Italy have been reported. Therefore, this study assessed the effectiveness of ustekinumab in a large cohort of Italian patients with refractory CD.
View Article and Find Full Text PDFBackground: Gastroenteropancreatic neuroendocrine neoplasms [GEP-NENs] have rarely been reported in association with inflammatory bowel diseases [IBDs].
Methods: An ECCO COllaborative Network For Exceptionally Rare case reports project [ECCO-CONFER] collects cases of GEP-NENs diagnosed in patients with IBD.
Results: GEP-NEN was diagnosed in 100 IBD patients; 61% female, 55% Crohn's disease, median age 48 years (interquartile range [IQR] 38-59]).
The peak of incidence of inflammatory bowel disease (IBD) overlaps with the peak of reproductive age. Moreover, women affected by IBD are often concerned with the possible negative effects of their disease and medications on pregnancy and birth outcomes. From a physician point of view, managing IBD in pregnancy is challenging.
View Article and Find Full Text PDFBackground: The long-term course of ulcerative colitis after a severe attack is poorly understood. Second-line rescue therapy with cyclosporine or infliximab is effective for reducing short-term colectomy but the impact in the long-term is controversial.
Objective: The purpose of this study was to evaluate the long-term course of acute severe ulcerative colitis patients who avoid early colectomy either because of response to steroids or rescue therapy.
Objective: The recurrence of Crohn's Disease after ileo-colonic resection is a crucial issue. Severe endoscopic lesions increase the risk of developing early symptoms. Prevention and treatment of post-operative Endoscopic Recurrence (ER) have been studied with conflicting results.
View Article and Find Full Text PDFBackground: Disease phenotype and outcome of late-onset Crohn's disease are still poorly defined.
Methods: In this Italian nationwide multicentre retrospective study, patients diagnosed ≥65 years (late-onset) were compared with young adult-onset with 16-39 years and adult-onset Crohn's disease 40-64 years. Data were collected for 3 years following diagnosis.
The patient's active involvement is an emerging hot-topic, which can be applied in to the management of chronic inflammatory bowel diseases (IBD). Since in this field most of the therapeutic strategies are not based on sturdy scientific evidences, the patient's role has become central and it is believed essential for any patients to have an active cognitive, behavioural and emotive profile. Moreover different patient's aspects should be considered, such as the patient's activation, the patient's engagement and the patient's disease knowledge.
View Article and Find Full Text PDFBackground And Aims: Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited. The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients.
Methods: All UC patients receiving thiopurine monotherapy at three tertiary IBD centers from 1995 to 2015 were identified.
Inflammatory bowel diseases, Crohn's disease and ulcerative colitis are chronic relapsing conditions that may result in progressive bowel damage, high risk of complications, surgery and permanent disability. The conventional therapeutic approach for inflammatory bowel diseases is based mainly on symptom control. Unfortunately, a symptom-based therapeutic approach has little impact on major long-term disease outcomes.
View Article and Find Full Text PDFBackground: Late-onset UC represents an important issue for the near future, but its outcomes and relative therapeutic strategies are yet poorly studied.
Aim: To better define the natural history of late-onset ulcerative colitis.
Methods: In a multicenter retrospective study, we investigated the disease presentation and course in the first 3 years in 1091 UC patients divided into 3 age-groups: diagnosis ≥65years, 40-64 years, and <40years.