Purpose: To report on a retrospective analysis of the cumulative experience from eight institutions using the GliaSite Radiotherapy System as a brachytherapy boost in the initial management of glioblastoma multiforme.
Methods And Materials: Eight institutions provided data on 20 patients with histologically proven glioblastoma multiforme with a median age of 59 years (range, 39-76) and median Karnofsky performance scale of 80 (range, 50-100). After maximal surgical debulking, patients were treated with GliaSite brachytherapy to a median dose of 50 Gy, followed by external beam radiotherapy to a median dose of 60 Gy (range, 46-60 Gy), for a cumulative dose escalation of 110 Gy (range, 84-130 Gy).
Objective: To review the cumulative experience of 10 institutions in treating recurrent malignant gliomas with the brachytherapy device, GliaSite Radiation Therapy System.
Methods: The patient population consisted of 95 patients with recurrent grade 3 or 4 gliomas, a median age of 51 years, and a median Karnofsky performance status score of 80. All patients had previously undergone resection and had received external beam radiotherapy as part of their initial treatment.
Purpose: The purpose of this study was to determine the effects of rotating a bone-patellar tendon- bone allograft during anterior cruciate ligament reconstruction on anteroposterior (AP) knee laxity and forces developed within the graft.
Type Of Study: In vitro biomechanical study using human cadaveric knees.
Methods: Thirteen fresh-frozen knee specimens received bone-patella tendon-bone allografts that were pretensioned at 30 degrees of flexion to restore AP laxity to that of the intact knee.