Publications by authors named "Arash Eidizadeh"
T cells are central to all currently effective cancer immunotherapies, but the characteristics defining therapeutically effective anti-tumor T cells have not been comprehensively elucidated. Here, we delineate four phenotypic qualities of effective anti-tumor T cells: cell expansion, differentiation, oxidative stress, and genomic stress. Using a CRISPR-Cas9-based genetic screen of primary T cells we measured the multi-phenotypic impact of disrupting 25 T cell receptor-driven kinases.
View Article and Find Full Text PDFAcross clinical trials, T cell expansion and persistence following adoptive cell transfer (ACT) have correlated with superior patient outcomes. Herein, we undertook a pan-cancer analysis to identify actionable ligand-receptor pairs capable of compromising T cell durability following ACT. We discovered that FASLG, the gene encoding the apoptosis-inducing ligand FasL, is overexpressed within the majority of human tumor microenvironments (TMEs).
View Article and Find Full Text PDFArticle Synopsis
- Somatic gene mutations can make cancer cells less susceptible to T-cell-based immunotherapies, particularly through specific gene alterations in melanoma cells.
- A large-scale CRISPR-Cas9 screen identified genes whose loss hinders CD8 T cell function, revealing that genes important for antigen presentation and interferon-γ signaling are often involved.
- The study pinpointed APLNR mutations in tumors resistant to immunotherapy, demonstrating how APLNR's interaction with JAK1 affects immune responses, ultimately impacting the effectiveness of certain cancer treatments in mouse models.