Relationship between mutations in severe hemophilia A and risk of inhibitor development: A large single-center study.

Background: One of the major problems for patients with severe hemophilia A (HA) is the development of neutralizing antibodies against factor VIII. This study aimed to analyze the molecular and clinical profiles of patients with severe HA and to determine if certain genetic variants predispose to inhibitor development in these patients.

Methods: A single-center study was conducted among patients with severe HA between March 20, 2000, and June 31, 2023.

Genotype-phenotype analyses of Iranian patients with hemophilia B (Leyden -) and hemophilia B (Leyden +): A single-center study.

Background: There is a high prevalence of inherited bleeding disorders in Iran, such as hemophilia A (HA) and hemophilia B (HB). This study aimed to analyze the molecular and clinical profiles of patients with HB.

Methods: A single-center study was conducted among patients with severe HB between March 20, 2000, and June 31, 2023.

Molecular and clinical profile of rare bleeding disorders: A single-center retrospective study.

Introduction: Due to their low frequency, there is little information on the molecular pathologies of rare bleeding disorders (RBD). Therefore, this study aimed to analyze the molecular and clinical profiles of patients with RBD.

Methods: A retrospective single-center study was conducted among patients with factor (F) II, FVII, FX, and FXIII deficiencies between March 20, 2000, and June 31, 2023.