Analytic model comparing the cost utility of TVT versus duloxetine in women with urinary stress incontinence.

Introduction And Hypothesis: The purpose of this study was to assess cost utility of duloxetine versus tension-free vaginal tape (TVT) as a second-line treatment for urinary stress incontinence.

Methods: A Markov model was used to compare the cost utility based on a 2-year follow-up period. Quality-adjusted life year (QALY) estimation was performed by assuming a disutility rate of 0.

Retrospective case modelling to assess the impact of early intervention for voiding dysfunction after retropubic tape. When is it best to intervene?

Introduction And Hypothesis: This study is a retrospective modelling of early intervention for voiding difficulties (VD) after retropubic tape insertion.

Methods: Chart review assessing Trial Without Catheter (TWOC) on day 2 and day 9 and long-term VD. Number needed to treat (NNT) analysis performed for presumed intervention on days 2 and 9.

Uterus conserving prolapse surgery--what is the chance of missing a malignancy?

Introduction And Hypothesis: Recently, there has been a move towards uterine preserving surgery in the management of pelvic organ prolapse. The negative implications of such surgery have not been delineated. This study aims to identify the risk of finding an unexpected malignancy in these cases.

Do women with overactive bladder have realistic expectations for therapy?

Introduction And Hypothesis: This study aims to determine what women with overactive bladder (OAB) perceive as 'cure', assesses treatment acceptability and adverse events. It also determines impact on quality of life (QoL) and correlates it with expectations from therapy.

Methods: In 153 women with predominant OAB symptoms, QoL and expectations regarding 'cure' were assessed using KHQ and a novel questionnaire.

Quality control in urodynamics: Analysis of an international multi-center study.

Aims: To review the quality of urodynamic traces collected as part of a multi-center Phase II drug trial of a medication for overactive bladder (OAB), in order to assess adherence to the Good Urodynamic Practice (GUP) guidelines. To assess inter-rater reliability (IRR) for the numerical cystometrogram variables, and for the diagnosis of detrusor overactivity (DO).

Methods: Two central reviewers assessed 50 cystometrograms, recording the presence or absence of DO and assessing compliance with GUP guidelines.

Current management of overactive bladder.

Purpose Of Review: The concept of overactive bladder has helped us address the problem of urgency and urge incontinence from a symptomatic perspective. In this review, we provide a critical summary of clinically relevant recent publications, focusing in particular on advances in our understanding of assessment methods and therapeutic interventions for overactive bladder in women.

Recent Findings: According to current definitions, the prevalence of overactive bladder in western nations is now estimated as 13.