Monitoring of Fluconazole and Caspofungin Activity against Candida glabrata Biofilms by Bioluminescence Imaging.

can attach to various medical implants and forms thick biofilms despite its inability to switch from yeast to hyphae. The current biofilm models only provide limited information about colonization and infection and usually require animal sacrifice. To gain real-time information from individual BALB/c mice, we developed a noninvasive imaging technique to visualize biofilms in catheter fragments that were subcutaneously implanted on the back of mice.