Publications by authors named "Arangalage D"
Thanks to impressive advances in the field of oncology over the last 30 years, there has been a significant rise in cancer survivors. Nowadays, cardiovascular disease is one of the leading causes of death in this patient population. Coronary artery disease (CAD) is a major problem due to shared risk factors, an aging population and in many cases induced and/or accelerated atherosclerosis by antitumoral treatment during and even decades after the end of cancer therapy.
View Article and Find Full Text PDFBackground: In patients with significant tricuspid regurgitation, cardiac magnetic resonance imaging (CMR) is the preferred method for the evaluation of right ventricular function and volumes. However validated thresholds are lacking.
Aim: The aim of this study was to evaluate CMR assessment of right ventricular volumes in patients with significant (moderate or severe) tricuspid regurgitation, and to define its association with outcomes.
Hepatic T1 Mapping as a Novel Cardio-Hepatic Axis Imaging Biomarker Early after STEMI.
Eur Heart J Cardiovasc Imaging
October 2024
Article Synopsis
- The study investigates the relationship between liver function and right ventricular (RV) function in STEMI patients using cardiovascular magnetic resonance (CMR).
- It found that higher native hepatic T1-values are associated with greater RV ischemic involvement and increased NT-proBNP levels, which are biomarkers related to heart strain.
- The research indicates that hepatic T1 values can be a useful diagnostic tool for detecting RV dysfunction in patients after an ST-elevation myocardial infarction.
Article Synopsis
- Immune-checkpoint inhibitors (ICIs) can lead to serious heart issues like myocarditis, which can also involve broader muscle-related symptoms, highlighting the need for understanding associated risks.
- A study conducted across 17 countries from 2014 to 2023 examined data from 748 patients to identify factors that predict severe outcomes related to these heart complications, using a statistical model for analysis.
- Key findings indicated that certain conditions (like active thymoma) and symptoms (like low heart function) significantly increased the risk of severe heart-related events, and a risk score created from these factors effectively predicted outcomes, validated in multiple cohorts.
Background: The transcaval (TCv) vascular approach is increasingly used in transcatheter aortic valve replacement (TAVR) in patients unsuitable for the gold-standard transfemoral approach. We aimed to evaluate the efficacy, safety, and clinical outcomes associated with TCv-TAVR.
Methods: A systematic review and meta-analysis was conducted by searching PubMed/Medline, Embase, and the Cochrane Library for all articles assessing the TCv approach published through December 2023.
Cardiac magnetic resonance imaging (CMR) is vital, but claustrophobia affects 10% of patients. The metaverse, an immersive virtual and augmented reality environment, has healthcare potential. We present a metaverse-based CMR simulation for claustrophobic patients.
View Article and Find Full Text PDFSystemic sclerosis (SSc) is a rare autoimmune disease (AD), characterised by early diffuse vasculopathy, activation of the immune response and progressive skin and internal organ fibrosis. In severe progressive diffuse SSc (dSSc), autologous hematopoietic stem cell transplantation (aHSCT) improves survival, despite its own risk of complications and transplant related mortality (TRM). We present herein the case of a dSSc patient undergoing aHSCT with low dose cyclophosphamide conditioning and sudden acute myopericarditis and cardiogenic shock, four weeks after a second mRNA SARS-CoV-2 vaccine (Pfizer) injection.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates the role of T2 values in the noninfarcted myocardium (NIM) after a heart attack (STEMI) to better understand tissue-level inflammation and its implications for patient outcomes.
- The research involved 171 patients and found that higher T2 values in the NIM were linked to larger heart muscle damage, poor heart function, and did not correlate with typical inflammatory markers.
- Patients with elevated NIM T2 values had a significantly higher risk of major cardiovascular events, particularly reinfarction, highlighting the potential of T2 mapping as a prognostic tool post-STEMI.
Article Synopsis
- The text discusses the transformative impact of digital technology in cardiology, highlighting the use of AI for diagnosing heart conditions.
- It mentions the role of ChatGPT in providing consultations, showcasing how AI can assist healthcare professionals.
- Additionally, the text touches on the educational potential of the Metaverse in training medical practitioners, while also addressing the challenges and promises of these technologies in the field of digital health.
Article Synopsis
- * Despite the presence of pericardial LGE, all patients were asymptomatic and did not require treatment for pericarditis, with no symptoms appearing in a year of follow-up.
- * The findings also indicated a correlation between the occurrence of pericardial LGE and the number of prior surgeries, along with histological findings of fibrosis and low-grade inflammation in some patients with severe LGE.
Objective: Despite recent advances in surgical and interventional techniques, knowledge on the management of carcinoid heart disease (CHD) remains limited. In a cohort of patients with liver metastases of midgut neuroendocrine tumours (NETs), we aimed to describe the perioperative management and short-term outcomes of CHD.
Methods: From January 2003 to June 2022, consecutive patients with liver metastases of midgut NETs and severe CHD (severe valve disease with symptoms and/or right ventricular enlargement) were included at Beaujon and Bichat hospitals.
Objectives: The identification of patients with mitral valve prolapse (MVP) presenting high arrhythmic risk remains challenging. Cardiovascular Magnetic Resonance (CMR) feature tracking (FT) may improve risk stratification. We analyzed the role of CMR-FT parameters in relation to the incidence of complex ventricular arrhythmias (cVA) in patients with MVP and mitral annular disjunction (MAD).
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- Immune checkpoint inhibitors (ICIs) have transformed cancer treatment by improving survival rates and quality of life, but most patients experience immune-related adverse events (irAEs), which can be serious or life-threatening.
- Early diagnosis and treatment of irAEs are crucial for enhancing long-term outcomes, yet guidelines for recognizing irAEs and the necessary laboratory test frequency are lacking.
- The report suggests specific laboratory and functional tests to better detect irAEs early, aiming to improve patient care and minimize the repetitive blood sampling currently required in ICI treatment.
Carcinoid heart disease (CHD) is the main complication of carcinoid syndrome (CS) associated with metastatic small intestine neuroendocrine tumours (NETs). The pathophysiology of CHD is partly understood but vasoactive hormones secreted by NETs, especially serotonin, play a major role, leading to the formation of fibrous plaques. These plaque-like deposits involve the right side of the heart in >90% of cases, particularly the tricuspid and pulmonary valves, which become thickened, retracted and immobile, resulting in regurgitation or stenosis.
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- ICB-myocarditis can mimic other heart issues like acute coronary syndrome, complicating quick diagnosis.
- A study of 261 patients revealed that 22.6% had coronary artery disease (CAD), with those undergoing revascularization having higher 90-day mortality rates.
- The presence of CAD alongside ICB-myocarditis can worsen outcomes, especially after revascularization, highlighting the need for careful diagnosis and management.
Background: Immune-checkpoint inhibitor-associated myocarditis (ICI-myocarditis) often presents with arrhythmias, but the prognostic value of early electrocardiogram findings is unclear. Although ICI-myocarditis and acute cellular rejection (ACR) following cardiac transplantation use similar treatment strategies, differences in arrhythmia burden are unknown.
Objective: To evaluate the association of electrocardiogram findings in ICI-myocarditis with myocarditis-related mortality and life-threatening arrhythmia.
Article Synopsis
- - The study evaluated the safety, image quality, and diagnostic effectiveness of stress perfusion-CMR imaging in patients with specific implantable devices—permanent pacemakers and defibrillators.
- - Out of 3743 stress-CMR exams, only 66 involved patients with devices, and imaging quality was found to be diagnostic in 98% of cases with no device malfunctions reported.
- - The results showed that stress perfusion-CMR effectively detected ischemia, correlating with significant coronary lesions in 9% of patients who tested positive for ischemia.