Publications by authors named "Arandia D"
Article Synopsis
- Human WHO grade 1 meningiomas, although typically benign, are responsible for about 50% of recurrent cases, highlighting the need for more research on their genetic profiles and patient outcomes.
- The study investigated 32 grade 1 meningiomas through whole exome sequencing, revealing diverse genetic variants mainly affecting specific genes, with distinct profiles linked to patient recurrence-free survival (RFS).
- The analysis identified four genetic profiles related to prognosis: two good-prognosis subgroups with high RFS rates and two poor-prognosis subgroups with significantly lower RFS rates, emphasizing the complexity of these tumors and their impact on treatment outcomes.*
Background: The prognostic impact of the expression profile of genes recurrently amplified in glioblastoma multiforme (GBM) remains controversial.
Methods: We investigated the RNA gene expression profile of epidermal growth factor receptor (), cyclin-dependent kinase 4 (), murine doble minute 4 (), and platelet derived growth factor receptor alpha () in 83 primary GBM tumors vs. 42 normal brain tissue samples.
Evidence indicates that a link between peptic ulcer disease (PUD) and selected psychosomatic factors may exist. A series of 70 consecutive male and female adult patients were categorized by peptic symptoms and divided into four groups: a) controls; b) gastric ulcer (GU); c) duodenal ulcer (DU); and d) chronic non-ulcer dyspepsia (CNUD). All patients were interviewed and asked to answer a questionnaire that included demographics, medical history and the incidence of negative life events.
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