Publications by authors named "Aran Yukseloglu"
Article Synopsis
- The study explored how genetic variations in CYP2C9, CYP3A4, and CYP2D6 might affect the effectiveness and safety of pain medications ibuprofen and oxycodone in children with acute fractures.
- Conducted on 210 children aged 4 to 16, results showed that while both medications provided similar pain relief, oxycodone users experienced significantly more adverse events than those taking ibuprofen.
- Additionally, children with the CYP2C9*2 allele had fewer adverse events with ibuprofen compared to those with the normal functioning CYP2C9*1 allele, indicating that certain genetic factors might influence medication safety.
Objective: To quantify the frequency and intensity of adverse events (AEs), commonly known as side effects, experienced by children receiving either ibuprofen or oxycodone for pain management following an acute fracture. Secondary objectives were to quantify functional outcome impairment and describe demographic and clinical characteristics associated with AEs.
Design: Observational cohort study.
For decades lysophosphatidylcholine (LPC, lysolecithin) has been used to induce demyelination, without a clear understanding of its mechanisms. LPC is an endogenous lysophospholipid so it may cause demyelination in certain diseases. We investigated whether known receptor systems, inflammation or nonspecific lipid disruption mediates LPC-demyelination in mice.
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