Uniform and stable hydrogel-filled liposome-analogous vesicles with a thin elastomer shell layer.

This study introduces a new type of uniform liposome-analogous vesicle with a highly stable shell structure in which water-in-oil-in-water double emulsion drops fabricated in a capillary-based microfluidic device are used as templates. The vesicles developed in this work consist of a poly(ethylene glycol) hydrogel core surrounded by a polyurethane (PU) film between 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) layers. Subjecting the double emulsion templates to UV irradiation leads to the formation of a PU elastomer film between the DPPC layers.

One-pot microfluidic fabrication of graphene oxide-patched hollow hydrogel microcapsules with remarkable shell impermeability.

Uniform hollow hydrogel microcapsules, composed of a graphene oxide platelet-patched shell, are fabricated in one step in a capillary-based microfluidic device. We demonstrate that patching a small amount of graphene oxide at the interfaces remarkably prevents the leakage of small molecules through the shell.

Microfluidic fabrication and permeation behaviors of uniform zwitterionic hydrogel microparticles and shells.

This study introduces a flexible and straightforward method for generating monodisperse complex hydrogel microparticles. For this, a water-in-oil emulsion was generated in a microcapillary device and then the emulsion drops were photo-polymerized to transfer them to hydrogel particles. The hydrogel microparticles were made of poly (2-methacryloyloxyethyl phosphorylcholine) that has an enhanced biocompatibility due to the phosphatidyl choline moiety in the backbone.