Epistaxis and Intradural-Extramedullary Haemorrhage in a Dog With Steroid Responsive Meningitis-Arteritis.

A 2-year-old female entire Golden Retriever with a history of being subdued was seen. Her physical and neurological examinations were initially unremarkable, but she acutely progressed to non-ambulatory paraparesis, with absent cervical or thoracolumbar hyperaesthesia. Magnetic resonance imaging of the vertebral column was performed, showing a well-defined, intradural-extramedullary mass at the level of the caudal aspect of L2 causing right-sided ventrolateral marked cord compression.

Cervical adenocarcinoma presenting as an ovarian torsion.

Background: Cervical adenocarcinoma is increasing in incidence and can rarely present as ovarian metastasis.Case: A 41-year-old female who presented with left lower quadrant pain and vomiting. Intra-operative findings revealed bilateral ovarian cysts with initial pathology results of mucinous ovarian adenocarcinoma.

Upcycling Graphite from Apent Li-Ion Battery with SiO via Mechano-Chemical Process as Next-Generation Anode for Li-Ion Capacitors.

Hybrid supercapacitors such as Lithium-ion capacitors (LICs) are one of the most modern energy storage devices of great research interest. The hybridization of the battery-type anode with the capacitive-type cathode brings out the synergic effect of enhanced energy density, power capability, long cycle life, and wide operating temperature. Herein, we introduce a simultaneous alloying-intercalation process from the recovered graphite: silicon monoxide (RG: SiO) composite as a negative electrode for the LIC applications with the activated carbon (AC) as a counter electrode.

Biogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activities.

Green nanotechnology is an effective treatment approach being used in cancer research with less adverse effects. This work describes the incorporation of silver nanoparticles synthesized from clitoria ternatea plant extract (Ag@CT NPs) into sodium alginate and gelatin polymer blends (SA/GEL) to produce Ag@CT-SA/GEL polymer beads using calcium chloride (CaCl) crosslinking agent. Both the formation and the effective incorporation of Ag@CT NPs into polymer blend have been proven by various spectroscopic analysis, surface morphology study and energy dispersive X-ray analysis.

A modified procedure for separating yeast peroxisomes from mitochondria.

Mitochondria and peroxisomes are mutually dependent organelles that share several membrane proteins that carry out the same function in both organelles. To study the unique features of these dually localized proteins in each of the two organelles, it is essential to separate mitochondria from peroxisomes. Isolating organelles from cells of Baker's yeast, Saccharomyces cerevisiae, is crucial for our understanding of the biogenesis and functions of proteins.

Universal penalized regression (Elastic-net) model with differentially methylated promoters for oral cancer prediction.

Background: DNA methylation showed notable potential to act as a diagnostic marker in many cancers. Many studies proposed DNA methylation biomarker in OSCC detection, while most of these studies are limited to specific cohorts or geographical location. However, the generalizability of DNA methylation as a diagnostic marker in oral cancer across different geographical locations is yet to be investigated.

Health-Related Quality of Life and its Determinants among School-going Adolescents: A Cross-sectional Study.

Background: Adolescents experience rapid physical, cognitive, and psychosocial growth in their transition from childhood to adulthood, affecting health outcomes and well-being. Health-related quality of life (HRQoL) is a useful indicator of health outcomes, assessed in the current study along with associated determinants.

Methods: A cross-sectional study was conducted among 634 randomly selected adolescents from 13 randomly selected schools in Gharwal division, Uttarakhand, India, from August 2019 to September 2020.

Optimal Timing of Cesarean Section Following Two or More Prior Cesareans: An Investigation Into Maternal and Neonatal Outcomes (a Two-Center Study).

Objective This study aimed to determine the optimal timing of elective cesarean sections for women with two or more prior cesarean deliveries by investigating maternal and neonatal outcomes across different gestational ages (37 weeks, 38 weeks, and 39 weeks). Methods A retrospective cohort study was conducted at Tawam and Kanad Hospitals in Al Ain, United Arab Emirates, including 435 women with previous cesarean deliveries. Data were collected on patient demographics, obstetric history, maternal complications, and neonatal outcomes, such as birth weight, appearance, pulse, grimace, activity, and respiration (APGAR) scores, neonatal intensive care unit (NICU) admissions, and length of NICU stay.

The Effect of Two Health Education Packages on Nutritional Knowledge, Practices, and Physical Activity Levels Among School-Going Adolescents in Rishikesh: A Cluster Randomized Trial.

Introduction Adolescence is a critical period known for presenting specific challenges in disease treatment and health promotion. Studies have highlighted that increased nutritional awareness is associated with healthier eating habits, while regular physical activity aids in controlling and preventing non-communicable diseases. Equipping adolescents with health education in schools prepares them to adopt and maintain healthy lifestyles throughout their lives.

Enhanced assembly stability for amine-based cationic glycolipid.

Glycolipids incorporating positive charges, mediated by an imidazolium cation, have shown potential for effective formulation of vesicular drug carriers, reflecting repulsive electrostatic forces, promoting the formation of nanosized assemblies and preventing unwanted Oswald ripening (Goh et al. (2019), ACS Omega 4, 17,039). Our continuous development of an assembly-based drug delivery system prompted us to investigate a pH-sensitive analogue, leading to the synthesis of a 6-amino-Guerbet glycoside.

Mechanically Exfoliated Graphite for Highly Reversible Na-Storage with Carbon Coated NaV(PO) Cathode with Low-Temperature Conditions.

Tremendous efforts are put forward to develop novel high-performance electrodes for Na-ion batteries (SIBs) in order to replace commercial Li-ion batteries (LIBs). Graphite, the most versatile anode for LIBs, fails to accommodate Naions owing to the poor thermodynamic stability of the binary graphite intercalation compound. This study aims to exfoliate the layers of graphite through a simple mechanical process at different time intervals (1, 5, 10, 20, 40, and 80 h) and examine the potential candidate for Na-storage in the presence of carbonate-based electrolytes.

Step-Up Management in Acute Pancreatitis: A Tertiary Care Center's Experience From Southern India.

Background The clinical spectrum of acute pancreatitis (AP) ranges from mild disease to severe form associated with multiorgan failure, prolonged hospital stay, high morbidity, and mortality. Acute necrotizing pancreatitis (ANP) is a severe form of AP. This study evaluates AP's outcomes after applying principles of the  approach in a tertiary healthcare center in south India.

The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites.

Contact-sites are specialized zones of proximity between two organelles, essential for organelle communication and coordination. The formation of contacts between the Endoplasmic Reticulum (ER), and other organelles, relies on a unique membrane environment enriched in sterols. However, how these sterol-rich domains are formed and maintained had not been understood.

Literature review and meta-analysis of environmental toxins associated with increased risk of Parkinson's disease.

Parkinson's disease (PD) is a neurodegenerative disorder and leading cause of death worldwide, whose pathogenesis has been linked to toxic environmental exposures. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (i) to compile, and group by exposure setting (non-specified general; residential; occupational), environmental factors reported to modulate the risk of developing PD and (ii) to map and geospatially analyze global regions of both research activity and paucity. Among the broader environmental settings, occupational exposures had the highest average odds ratio value at 3.

Opioid use disorder in pediatric populations: considerations for perioperative pain management and precision opioid analgesia.

Introduction: Opioids are commonly used for perioperative analgesia, yet children still suffer high rates of severe post-surgical pain and opioid-related adverse effects. Persistent and severe acute surgical pain greatly increases the child's chances of chronic surgical pain, long-term opioid use, and opioid use disorder.

Areas Covered: Enhanced recovery after surgery (ERAS) protocols are often inadequate in treating a child's severe surgical pain.

Prevalence rates of neurodegenerative diseases versus human exposures to heavy metals across the United States.

Novel means are needed to identify individuals and subpopulations susceptible to and afflicted by neurodegenerative diseases (NDDs). This study aimed to utilize geographic distribution of heavy metal sources and sinks to investigate a potential human health risk of developing NDDs. Known or hypothesized environmental factors driving disease prevalence of Alzheimer's Disease (AD), Parkinson's Disease (PD), and amyotrophic lateral sclerosis (ALS) are heavy metals, including arsenic (As), cadmium (Cd), manganese (Mn) and mercury (Hg).

Surface modification of a commercial bone plate (Ti6Al4V) implant for improved antibacterial and cytocompatibility via thermal dewetting of a silver thin film.

The high demand for bone grafts has motivated the development of implants with excellent osteogenic activity, whereas the risk of implant-associated infection, particularly given the rise of antimicrobial resistance, has compelled the development of implants with innovative antimicrobial strategies in which a small amount of bactericidal agent can effectively kill a wide range of bacteria. To induce antibacterial property, the surface of Grade-5 bone plate titanium implants used in clinical applications was modified using direct current (DC) sputter coating followed by thermal annealing. The 15 nm silver film-coated implants were thermally annealed in the furnace for 15 min at 750 °C.

Enhanced control over size, areal density, and shape of substrate-supported Au and Ag nanoparticles by solid-state dewetting and alloying.

The ability to manipulate the dimensions, areal density, and form of substrate-supported Au and Ag nanoparticles (NPs) is highly desirable for utilizing their plasmonic properties in biosensing, photovoltaics, and nanophotonic applications. The transformation of thin films into the substrate-supported nanostructures by solid-state dewetting (SSD), provides an avenue to manipulate the dimensional aspects of nanostructures simply and cost-effectively on a large scale. However, spontaneous agglomeration of the film produces randomly distributed and non-uniform nanostructures that must be controlled.

Hip, knee, and shoulder arthroplasty in patients with a history of solid organ transplant: A review.

Solid organ transplants (SOT) have evolved into life-saving interventions for end-stage diseases affecting vital organs. Advances in transplantation techniques, donor selection, and immunosuppressive therapies have enhanced outcomes, leading to a growing demand for SOT. Patients with a solid organ transplant are living long enough to develop the same pathologies which are indicated for joint replacement surgery in the general population.

Chemoprevention of neuroblastoma: progress and promise beyond uncertainties.

Neuroblastoma is the most common extracranial solid tumor in children and comprises one-tenth of all childhood cancer deaths. The current clinical therapy for this deadly disease is multimodal, involving an with alternating regimens of high-dose chemotherapeutic drugs and load reduction surgery; a with more intensive chemotherapy, radiotherapy, and stem cell transplant; and a with immunotherapy and immune-activating cytokine treatment. Despite such intensive treatment, children with neuroblastoma have unacceptable life quality and survival, warranting preventive measures to regulate the cellular functions that orchestrate tumor progression, therapy resistance, metastasis, and tumor relapse/recurrence.