Publications by authors named "Arafa Salam"
Article Synopsis
- There is evidence that inhibitory killer cell immunoglobulin-like receptors (iKIRs) can influence T cell responses and survival, particularly in chronic viral infections.
- In a study with humans, it was found that individuals with more iKIR-ligand gene pairs had significantly longer-lasting memory CD8+ T cells, with lifespans increasing from 125 days to 250 days.
- The research suggests that iKIR-ligand genotypes play a crucial role in T cell survival and immune aging, independent of iKIR expression on the T cells themselves.
Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural killer cells, where they play a key role in the regulation of innate immune responses. Recent studies show that inhibitory KIRs can also affect adaptive T cell-mediated immunity. In mice and in human T cells in vitro, inhibitory KIR ligation enhanced CD8 T cell survival.
View Article and Find Full Text PDFHuman neutrophils have traditionally been thought to have a short half-life in blood; estimates vary from 4 to 18 hours. This dogma was recently challenged by stable isotope labeling studies with heavy water, which yielded estimates in excess of 3 days. To investigate this disparity, we generated new stable isotope labeling data in healthy adult subjects using both heavy water (n = 4) and deuterium-labeled glucose (n = 9), a compound with more rapid labeling kinetics.
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