Neoadjuvant immunotherapy and oncolytic virotherapy in HPV positive and HPV negative skin cancer: A comprehensive review.

Skin cancer is the most common new cancer among Caucasians. This cancer has different types, of which non-melanoma skin cancer is the most common type. Various factors affect this disease, one of which is viral infections, including HPV.

In COVID-19 Health Messaging, Loss Framing Increases Anxiety with Little-to-No Concomitant Benefits: Experimental Evidence from 84 Countries.

The COVID-19 pandemic (and its aftermath) highlights a critical need to communicate health information effectively to the global public. Given that subtle differences in information framing can have meaningful effects on behavior, behavioral science research highlights a pressing question: Is it more effective to frame COVID-19 health messages in terms of potential losses (e.g.

A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.

The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation.

Heterogeneity in kinesin function.

The kinesin family proteins are often studied as prototypical molecular motors; a deeper understanding of them can illuminate regulation of intracellular transport. It is typically assumed that they function identically. Here we find that this assumption of homogeneous function appears incorrect: variation among motors' velocities in vivo and in vitro is larger than the stochastic variation expected for an ensemble of "identical" motors.

Operative treatment of progressive deformity in spinal tuberculosis.

We report on 14 patients with tuberculosis of the spine treated by operation. All had disease of three or more vertebrae with involvement of both the anterior and posterior columns and a progressive kyphotic deformity in spite of conservative treatment. We consider such spines to be 'unstable' and have found that anterior as well as posterior fusion with instrumentation is necessary.

Electronic design of a multichannel programmable implant for neuromuscular electrical stimulation.

An advanced stimulator for neuromuscular stimulation of spinal cord injured patients has been developed. The stimulator is externally controlled and powered by a single encoded radio frequency carrier and has four independently controlled bipolar stimulation channels. It offers a wide range of reprogrammability and flexibility, and can be used in many neuromuscular electrical stimulation applications.

Reduction of bladder outlet resistance by selective sacral root stimulation using high-frequency blockade in dogs: an acute study.

Detrusor-sphincter dyssynergia is a main problem in supra-sacral spinal cord injured patients. The problem of high pressure voiding is also encountered in most electrically induced micturition because of the mixed somatic and autonomic fiber components of the ventral sacral root. We studied the effect of selective high-frequency blockade at the sacral nerve root in an acute spinalized canine model to prevent the deleterious consequences associated with the elevated bladder outlet resistance.

Implantable volume monitor and miniaturized stimulator dedicated to bladder control.

This paper describes a new miniaturized implantable bladder controller that is composed of 4 main parts: a volume monitoring device based on the tomography approach, a fully programmable miniaturized central processor and stimulator, a bidirectional data and power link, and an external controller. The proposed system is intended to restore both normal bladder functions (retention and voiding) to spinal cord injured patients. The system contains a mixed-signal (analog/digital) feedback loop to command the bladder functions through neuromuscular stimulation techniques.

Implantable multiprogrammable microstimulator dedicated to bladder control.

An implantable multiprogrammable microstimulator that is intended to restore normal bladder functions (retention and incontinence) to spinal cord injured patients is presented. The implantable microstimulator circuitry is externally controlled and is powered by a single encoded radio frequency carrier and has four bipolar (eight monopolar) independently controlled channels. It offers a higher degree of reprogrammability and flexibility and can be used in any neuromuscular applications.

Epidemiological survey of spinal cord injury: A study of 377 patients.

The total number of patients admitted to the Spinal Cord Injury Unit, Riyadh Central Hospital, Riyadh, Saudi Arabia from June 1979 to March 1984 approached 450 patients. Of those, 377 (369 males and 8 females) patients with complete records and sustaining traumatic injury were studied. The patients were divided into four groups: cervical, dorsal, dorsolumbar and lumbar.

Evaluation of radiological investigations in spinal tuberculosis.

Thirty-four cases of spinal tuberculosis were investigated by plain radiography, computerised tomography and myelography followed by computerised tomography. All the patients were operated on and the findings compared with the results of the investigations.

Bifacetal dislocation following tuberculosis of the cervical spine.

We present a case of bifacetal dislocation following tuberculosis of the cervical spine with a minimal neurological deficit and a huge retropharyngeal abscess in a 14-year-old Saudi child. Treatment was by anterior debridement, decompression and bone grafting followed 2 weeks later by posterior wiring and fusion from C2 to C5. We also review the literature relating to this subject.

Spinal brucellosis.

The findings in 44 patients with back pain and brucellosis are described. Radiological changes tended to occur in older patients with a longer duration of disease. The younger patients more often experienced an acute arthritis with sacroiliitis resembling a reactive disease.

Atypical forms of spinal tuberculosis.

Twenty-three patients with atypical forms of spinal tuberculosis treated between 1975 and 1985, are described. All presented with signs and symptoms of compression of the spinal cord or cauda equina, ranging from paraesthesiae and increasing weakness of extremities to paraplegia and loss of sphincter control. None of them showed visible or palpable spinal deformity nor the typical radiographic appearance of destruction of the intervertebral disc and the two adjoining vertebral bodies.

Desmoplastic fibroma--a rare tumour in a rare site.

We report the occurence of a desmoplastic fibroma in the terminal phalanx of the big toe in a 42-year-old male. The tumour is rare, only 66 cases have been reported in the English language journals. The case history together with review of the literature is presented.

Osteitis of the humerus following BCG vaccination.

A 22-month-old Saudi child developed a granulomatous lesion of the left humerus following BCG vaccination in the overlying deltoid area 15 days after birth. The clinical picture, investigations and the histopathology reports are presented. The literature regarding BCG vaccine complications and their frequency is reviewed.

Severe mincer injuries of the hand in children in Saudi Arabia.

A review of twenty-two children with a mean age of 1.9 +/- 0.3 years who sustained injuries to the fingers and hand by domestic mincer machine.

Is avoidance of sunlight a cause of fractures of the femoral neck in elderly Saudis?

A study of the frequency of admitted cases of femoral neck fractures to Riyadh Central Hospital, Riyadh, Saudi Arabia, showed admission of 95 patients over 40 years of age in a period of one year. The male to female ratio was 64% males to 36% females. Vitamin D nutritional status of patients with fractures of the neck of the femur expressed as 25-(OH)D3 was significantly lower (5.

Sunlight and vitamin D status in normal Saudi subjects.

Serum levels of the circulating form of vitamin D3, 25-hydroxycholecalciferol [25-(OH)D3], were determined in 59 university students, 26 males and 33 females, aged 18 to 26 yr and in 24 elderly subjects, 13 males and 11 females, with a mean age of 62 +/- 13 yr. The level of 25-(OH)D3 was significantly lower in the elderly persons (p less than 0.001) than in young students of both sexes, and was significantly higher in females than in males.

The wrinkly skin syndrome: a report of two siblings from Saudi Arabia.

A brother and sister born to a Saudi couple showed aging appearance, wrinkled skin over the hands and feet, inelastic skin, prominent veins over the hands, and other musculoskeletal and connective tissue manifestations. Both children were small for their age and had congenital dislocation of the hips. The paper describes the main manifestations and compares them with the previously described two families.

Congenital spinal extradural cyst (lateral meningocele) simulating acute transverse myelitis. Report of a case.

Congenital spinal extradural cysts are rare and may be the cause of acute paraplegia. In their clinical features they closely resemble acute transverse myelitis. Immediate decompression of the spinal cord and removal of the cyst may lead to restoration of normal function.