Descending Colon Leiomyoma: A Case Report and Literature Review.

Leiomyoma is defined as a benign proliferation of smooth muscle cells. Smooth muscle tumors are considered the second-most common mesenchymal neoplasm in the gastrointestinal (GI) tract. It typically occurs incidentally in the large bowel.

Emerging trends and recent advances in MXene/MXene-based nanocomposites toward electrochemiluminescence sensing and biosensing.

Electrochemiluminescence (ECL) sensing systems have surged in popularity in recent years, making significant strides in sensing and biosensing applications. The realization of high-throughput ECL sensors hinges on the implementation of novel signal amplification strategies, propelling the field toward a new era of ultrasensitive analysis. A key strategy for developing advanced ECL sensors and biosensors involves utilizing novel structures with remarkable properties.

Approaches for the Efficient Removal of Fluoride from Groundwater: A Comprehensive Review.

Contamination of groundwater with fluoride represents a significant global issue, with high concentrations posing serious public health threats. While fluoride is a critical element in water, excessive levels can be detrimental to human health and potentially life-threatening. Addressing the challenge of removing fluoride from underground water sources via nanotechnological approaches is a pressing concern in environmental science.

Infliximab is an effective option in patients with ulcerative colitis previously exposed to full subcutaneous anti-TNF agent: Results from a real-world multicenter study.

Background: Data on infliximab efficacy in bio-exposed patients with ulcerative colitis (UC) are limited.

Aims: To evaluate infliximab effectiveness and its predictors in UC patients with prior exposure to subcutaneous (SC) anti-TNF agent.

Methods: In this multicenter retrospective study (8 centers), we included all consecutive UC patients with prior exposure to subcutaneous anti-TNF, starting infliximab for symptomatic UC, excluding acute severe colitis.

A multichannel closed bipolar platform to visual electrochemiluminescence sensing of caffeic acid as a model: Potential for multiplex detection.

In this study, a fully-featured electrochemiluminescence (ECL) sensing platform based on a multichannel closed bipolar system (closed-BP, C-BP) for the determination of caffeic acid (CA) was successfully developed. The system comprises three individual reservoirs connected to each other by two pairs of gold rods as bipolar electrodes. Moreover, a single pair of gold rods functions as the driving electrodes.

White matter integrity assessment in spinocerebellar ataxia type 2 (SCA2) patients.

Aim: To assess the burden of white matter (WM) damage in the cerebrum and cerebellum of spinocerebellar ataxia type 2 (SCA2) patients in an attempt to identify key regions affected by the neurodegenerative processes using diffusion tensor imaging (DTI).

Materials And Methods: Nine SCA2 patients and 16 age-matched healthy controls were examined twice (SCA2 patients 3.6 ± 0.

A rare case of fatal gastrointestinal basidiobolomycosis.

Basidiobolomycosis is an uncommon fungal infection caused by the environmental saprophyte . Basidiobolomycosis typically manifests as a subcutaneous infection, and rarely affects the gastrointestinal tract. It lacks a distinct clinical manifestation, and most initial cases are incorrectly identified.

CpG island status as an epigenetic alteration for NIS promoter in thyroid neoplasms; a cross-sectional study with a systematic review.

Background: Gene silence via methylation of the CpG islands is cancer's most common epigenetic modification. Given the highly significant role of NIS in thyroid cancer (TC) differentiation, this cross-sectional study aimed to investigate the DNA methylation pattern in seven CpG islands (CpG1-7 including +846, +918, +929, +947, +953, +955, and +963, respectively) of the NIS promoter in patients diagnosed with papillary (PTC), follicular (FTC), and multinodular goiter (MNG). Additionally, a systematic review of the literature was conducted to compare our results with studies concerning methylation of the NIS gene promoter.

Comparison of the effect of bioterrorism education through two methods of lecture and booklet on the knowledge and attitude of nurses of Shams Al-Shomus Nezaja Hospital.

Background: Today, considering the importance of bioterrorism, it may be time to assess the risk of bioterrorism as an important priority. Nurses, as the broadest group of therapy group, are very influential in this regard. General aim: To determine the impact of bioterrorism education through two methods of lectures and booklets on the knowledge and attitude of nursing staff.

Utilizing the circulating tumor markers in diagnosis and management of medullary thyroid cancer.

Medullary thyroid cancer (MTC) is the third frequent subtype of thyroid cancer-driving from thyroid C-cells. The first-line strategy to treat MTC is surgery, but tumor recurrence and patients' mortality rate have still been demonstrated in approximately 4-10% of MTC cases. Therefore, to treat and prevent the progressive form of the disease, the early diagnosis of MTC is assumed to play a critical role.

White blood count, D-dimers, and ferritin levels as predictive factors of pulmonary embolism suspected upon admission in noncritically ill COVID-19 patients: The French multicenter CLOTVID retrospective study.

Background: A high prevalence of pulmonary embolism (PE) has been described during COVID-19. Our aim was to identify predictive factors of PE in non-ICU hospitalized COVID-19 patients.

Methods: Data and outcomes were collected upon admission during a French multicenter retrospective study, including patients hospitalized for COVID-19, with a CT pulmonary angiography (CTPA) performed in the emergency department for suspected PE.

D-Dimer Level and Neutrophils Count as Predictive and Prognostic Factors of Pulmonary Embolism in Severe Non-ICU COVID-19 Patients.

The incidence of pulmonary embolism (PE) is high during severe Coronavirus Disease 2019 (COVID-19). We aimed to identify predictive and prognostic factors of PE in non-ICU hospitalized COVID-19 patients. In the retrospective multicenter observational CLOTVID cohort, we enrolled patients with confirmed RT-PCR COVID-19 who were hospitalized in a medicine ward and also underwent a CT pulmonary angiography for a PE suspicion.

Escape from natural enemies depends on the enemies, the invader, and competition.

The enemy release hypothesis (ERH) attributes the success of some exotic plant species to reduced top-down effects of natural enemies in the non-native range relative to the native range. Many studies have tested this idea, but very few have considered the simultaneous effects of multiple kinds of enemies on more than one invasive species in both the native and non-native ranges. Here, we examined the effects of two important groups of natural enemies-insect herbivores and soil biota-on the performance of (native to Europe but invasive in the USA) and (native to the USA but invasive in Europe) in their native and non-native ranges, and in the presence and absence of competition.

Volumetric measures of the paralyzed vocal fold using computerized tomography; its clinical implication.

Objective: To report the volumetric measures of the paralyzed vocal fold in patients undergoing injection laryngoplasty.

Material And Method: All the medical records of patients with unilateral vocal fold paralysis who had high resolution computerized tomography scan of the neck and chest prior to injection laryngoplasty between October 2015 and May 2018 were included. Volumetric evaluation of the vocal folds was performed by measuring the vocal fold height using coronal images and the vocal fold length and width using axial images.

A reproducible and safe at-home allogeneic haematopoietic cell transplant program: first experience in Central and Southern Europe.

In 2015, we implemented an at-home allogeneic haematopoietic cell transplant (allo-HCT) program. Between 2015 and 2018, 252 patients underwent allo-HCT; 41 patients underwent allo-HCT in the at-home program (46% myeloablative; 63% unrelated donor; 32% posttransplant cyclophosphamide), and these patients were compared with 39 in-patients; safety, capacity to release beds for other programs, and economic efficiency cost were evaluated. We observed a lower incidence of febrile neutropenia in the at-home group compared with that in the in-patient group (32% versus 90%; p < 0.

Retroperitoneal Ganglioneuroma (GN): Case report in 14 years old boy.

Introduction: The ganglioneuroma is a rare tumor arising from sympathetic nervous system, which is composed of gangliocytes and mature stroma.

Presentation Of The Case: A retroperitoneal ganglioneuroma was found in a 14 years old Saudi boy, presented with recurrent vomiting. CT image showing a retroperitoneal cyst near the inferior vena cava and right iliac vessels.

Survival and outcomes after laparoscopic versus open curative resection for colon cancer.

Background: Many studies have shown that open and laparoscopicsurgery for resection of colonic cancers produce similar short- and long-term results, but no data have been reported from Saudi Arabia.

Objective: Compare 3-year disease-free and overall survival after laparoscopic versus open curative resection for potentially curable colon cancer.

Design: Multicenter retrospective cohort study.

A case series of actinomycosis from a single tertiary care center in Saudi Arabia.

Actinomycosis is an uncommon but curable chronic infection caused by spp. The cervicofacial region is the most susceptible to infection; however, other sites may also become infected. Data on the current prevalence of this rare disease in Riyadh, Saudi Arabia is lacking.

Thalamic volume and dimensions on MRI in the pediatric population: Normative values and correlations: (A cross sectional study).

Background: Diagnoses of thalamic atrophy in children are based on experts' judgments. No normative measures exist for aiding objective diagnoses. Our aim was to determine normative two-dimensions(2D) and volume measurements of the thalamus in normally developing children.

Thermal coupling impact on an MMW carrier generated using two free-running DFB lasers on glass.

In this Letter, the impact of thermal coupling between two glass laser cavities on a heterodyned signal for millimeter-wave frequency generation is presented. In addition to a narrow heterodyne linewidth estimated to be lower than 1 kHz, the frequency drift is reduced to ±16.5  ppm/7  s.

Development of Saudi e-health literacy scale for chronic diseases in Saudi Arabia: using integrated health literacy dimensions.

Objective: Health literacy has become a global issue, and it is important that patients and individuals are able to use information technology to access health information and educational services. The research objective is to develop a Saudi e-health literacy scale (SeHL) for measuring e-health literacy among Saudis suffering from non-communicable diseases (NCD).

Methods: Overall, 14 relevant papers in related interdisciplinary fields were reviewed to select the most useful literacy dimensions.

Heterologous expression of anti-apoptotic human 14-3-3β/α enhances iron-mediated programmed cell death in yeast.

The induction of Programmed Cell Death (PCD) requires the activation of complex responses involving the interplay of a variety of different cellular proteins, pathways, and processes. Uncovering the mechanisms regulating PCD requires an understanding of the different processes that both positively and negatively regulate cell death. Here we have examined the response of normal as well as PCD resistant yeast cells to different PCD inducing stresses.

Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms.

Iron is an essential micronutrient that is problematic for biological systems since it is toxic as it generates free radicals by interconverting between ferrous (Fe) and ferric (Fe) forms. Additionally, even though iron is abundant, it is largely insoluble so cells must treat biologically available iron as a valuable commodity. Thus elaborate mechanisms have evolved to absorb, re-cycle and store iron while minimizing toxicity.

Identification of human ferritin, heavy polypeptide 1 (FTH1) and yeast RGI1 (YER067W) as pro-survival sequences that counteract the effects of Bax and copper in Saccharomyces cerevisiae.

Ferritin is a sub-family of iron binding proteins that form multi-subunit nanotype iron storage structures and prevent oxidative stress induced apoptosis. Here we describe the identification and characterization of human ferritin, heavy polypeptide 1 (FTH1) as a suppressor of the pro-apoptotic murine Bax sequence in yeast. In addition we demonstrate that FTH1 is a general pro-survival sequence since it also prevents the cell death inducing effects of copper when heterologously expressed in yeast.

Home management of acute medical complications in cancer patients: a prospective pilot study.

Background: The development of reliable alternatives to conventional hospitalization in patients with cancer would have great clinical and economical value. The aim of the present study was to assess the feasibility of a home-based nursing intervention model as a safe alternative for the management of acute medical complications in cancer patients who would otherwise require conventional hospitalization.

Patients And Methods: From October 2013 to October 2014, we prospectively evaluated the outcomes of consecutive acute medical episodes treated at home under the home-based intervention program named the Bridge Project (BP).