Curcumin and targeting of molecular and metabolic pathways in multiple sclerosis.

Multiple sclerosis (MS) is a life-threading disease that poses a great threat to the human being lifestyle. Having said extensive research in the realm of underlying mechanisms and treatment procedures, no definite remedy has been found. Over the past decades, many medicines have been disclosed to alleviate the symptoms and marking of MS.

Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-κB Activity.

Background: Dapagliflozin, a selective Sodium-glucose cotransporter-2 (SGLT2) inhibitor, has been shown to play a key role in the control and management of metabolic and cardiac diseases.

Objective: The current study aims to address the effects of dapagliflozin on the expression of fractalkine (FKN), known as CX3CL1, and its receptors CX3CR1, Nuclear factor-kappa B(NF-κB) p65 activity, Reactive oxygen species (ROS), and inflammation in LPS-treated H9c2 cell line.

Methods: H9c2 cells were cultured with lipopolysaccharide (LPS) to establish a model of LPS-induced damage, and then, subsequently were treated with dapagliflozin for 72 h.

Estradiol modulated colorectal cancer stem cells bioactivity and interaction with endothelial cells.

This study aimed to evaluate the modulatory role of sex-related hormone estradiol on cancer stem cells with the origin of colorectal adenocarcinoma in vitro. Cancer stem cells were incubated with 100 nM estradiol for 48 h. The cell survival rate was analyzed using the MTT assay.

Advanced platelet-rich fibrin plus gold nanoparticles enhanced the osteogenic capacity of human mesenchymal stem cells.

Objectives: There is still insufficient clinical evidence of platelet-rich fibrin beneficial effects on bone regeneration. Gold nanoparticles have been shown to enhance osteogenic differentiation and bone mineralization. The purpose of this study was to investigate the effect of advanced-platelet-rich fibrin modified by gold nanoparticles on the osteoblastic differentiation of human mesenchymal stem cells.

Modulatory effect of photobiomodulation on stem cell epigenetic memory: a highlight on differentiation capacity.

Differentiation potential of stem cells into various lineages makes these cells as promising sources to treat multiple diseases. In this regard, the use of different strategies and protocols to increase differentiation capacity is highly demanded. Low-level laser therapy, a relatively noninvasive technique, has the capacity to accelerate the healing of numerous injuries and a portion of restorative capacity could be correlated with the stem cell activation and differentiation.

Collagen-alginate-nano-silica microspheres improved the osteogenic potential of human osteoblast-like MG-63 cells.

Modular bone tissue engineering is touted as an alternative approach to replace the damaged bone tissue. Hydrogel microcapsules could promote therapeutic properties by providing 3D condition and an increased cell-to-cell interaction. We investigated the osteogenic properties of alginate-nano-silica hydrogels enriched with collagen and gelatin on human osteoblast-like MG-63 cells.

Photo-modulation of zinc phthalocyanine-treated breast cancer cell line ZR-75-1 inhibited the normal tumor activity in vitro.

Regarding post-complication of convenient therapies against breast cancer, the emergence of effective approaches is essential. Photodynamic therapy is touted as a novel invasive therapeutic approach by the application of a photosensitizer promoted by laser irradiation. This study aimed to investigate the combined regime of low-level laser irradiation with zinc phthalocyanine in human breast cancer ZR-75-1 cell line.

Effect of Motivational Interviewing on Using Intrauterine Device in Women at High Risk for Pregnancy.

Background: Reproductive health programs help women live healthier. Family planning consultation is an important component of reproductive health. A good family planning consultation can increase the use of effective birth control methods and improve the life quality of people, specifically of those at high risk.

Clamping of fine Kirschner wires in external fixators.

In Ilizarov circular (ring) external fixators, fine Kirschner wires are used to fix the bone to the fixator. Clamping of the wires to the rings with different bolt torques has been studied. However, the relation between the bolt torque and the fixation load applied to the wire was not investigated.

Routine programs of health care systems as an opportunity toward communication skills training for family physicians: A randomized field trial.

Background: To have high-quality primary health care services, an adequate doctor-patient communication is necessary. Because of time restrictions and limited budget in health system, an effective, feasible, and continuous training approach is important. The aim of this study is to assess the appropriateness of a communication skills training program simultaneously with routine programs of health care system.

International Students of Isfahan University of Medical Sciences: A Survey about Their Needs and Difficulties.

Conflict Of Interest: none declared.

Introduction: International students experience difficult situations in a foreign country that may intensify other problems, which are expected in these situations and may have harmful effects on the potential function of students. As the main problems of international students may vary in different situations, the aim of this study was to investigate the main problems of international students in Iran.

Belonging to a peer support group enhance the quality of life and adherence rate in patients affected by breast cancer: A non-randomized controlled clinical trial.

Background: Breast cancer is the most common cancer in women. It seems that breast cancer patients benefit from meeting someone who had a similar experience. This study evaluated the effect of two kinds of interventions (peer support and educational program) on quality of life in breast cancer patients.

Characterization of enteroaggregative Escherichia coli (EAEC) clinical isolates and their antibiotic resistance pattern.

Objectives: Enteroaggregative Escherichia coli (EAEC) strains are an emerging type of diarrheagenic E. coli. The aim of this study was to investigate the frequency of EAEC in children with diarrhea by polymerase chain reaction (PCR) method targeting the pCVD432 gene.

Investigating the relation of social support functions and the demographic features of diabetic patients.

Background: Social support is a form of social capital which can be related to the health of patients. Chronic diseases, such as diabetes, are incurable but they can be controlled. However, the patient is always facing stressful physical, mental and social factors.

Evaluation of selective and nonselective media for isolation of Helicobacter pylori from gastric biopsy specimens.

The aim of the present study was to compare six media, three selective and three nonselective media, to determine the best combination of media for the primary isolation of Helicobacter pylori. Over a period of 8 months, mucosal antral biopsy specimens were obtained from 97 dyspeptic patients undergoing endoscopy. Biopsy samples were plated in parallel on all six media.

Analytical modelling of kirschner wires in Ilizarov circular external fixators using a tensile model.

Mechanical characteristics of orthopaedic fixators, such as the stiffness and stability, directly influence the mechanobiological environment in which the bone is healed. In circular external fixators, the transfixing Kirschner wires are the major contributors to the biomechanics involved. A comprehensive understanding of the mechanical behaviour of the wires is therefore the key to biomechanical analysis of the Ilizarov fixator.

Analytical modelling of Kirschner wires in Ilizarov circular external fixator as pretensioned slender beams.

Transfixing thin Kirschner wires (K-wires) are the key components of the Ilizarov fixator regarding its axial stiffness, which affects the mechanobiological environment in which bone is healed. Mechanically speaking, K-wires are slender beams that are axially tensioned, then fixed and transversely loaded. The existing solutions to such a problem either do not accommodate any axial loading prior to transverse loading, or do not account for the change in the axial load (reaction) due to transverse loading.

Pattern of complementary and alternative medicine use in urban population.

Background: To determine the prevalence and patterns of Complementary and Alternative Medicine (CAM) use in urban population in Isfahan.

Methods: In a crossâ€"sectional study through two-stage sampling methods, 870 individuals were selected from Isfahan Province, center of Iran. We selected 20 clusters randomly and chose one household from each cluster by chance then 24 households were included consequently.

Normative reference values for lung transfer factor in Isfahan, Iran.

Objectives And Background: Transfer factor or carbon monoxide diffusing capacity (DL(CO)) is a particularly valuable test of the appropriateness of gas exchange across the alveolocapillary membrane. The purpose of this study is to derive predictive equations for DL(CO) and its derivative volume-corrected DL(CO) (DL(CO)/VA) measured by single-breath method in a large non-smoking population sample in Isfahan.

Methodology: We evaluated 1429 randomly selected subjects (732 men, aged 5-85 years).