The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women.

Investigations suggest the benefits of low-level laser therapy (LLLT) to improve noninvasive body contouring treatments, inflammation, insulin resistance and to reduce body fat. However, the mechanism for such potential effects in association with exercise training (ET) and possible implications in browning adiposity processes remains unclear. Forty-nine obese women were involved, aged between 20 and 40 years with a body mass index (BMI) of 30-40 kg/m.

Photonic technology for the treatments of venous and arterial ulcers: Case report.

In this report, we report a case study on a 50-year-old male patient with different chronic wounds, such as venous ulcer and arterial ulcer in both legs. These wounds have persisted for more than 10 years, despite the different treatments applied, including, different dressings, hyperbaric camera, as well as the used of several medicines of oral and topical application. The case is addressed with the aim to evaluate if treatment that uses combined techniques such as low level laser therapy (LLLT), photodynamic therapy and cellulose membrane is able to improve healing and reduction of time of treatment in those types of chronic wounds.

Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats.

The cause of Alzheimer's disease (AD) remains uncertain. The accumulation of amyloid peptides (Aβ) is the main pathophysiological hallmark of the disease. Spatial deficit is an important initial sign of AD, while other types of memory impairments that appear in later stages.

Clinical and Radiologic Considerations for Idiopathic Superior Mesenteric Artery Syndrome.

Superior mesenteric artery (SMA) syndrome often occurs in the setting of rapid weight loss and scoliosis corrective spinal surgery. A reduction of fat around the third part of the duodenum can predispose the duodenum to compression and obstruction by the SMA as it emerges from the abdominal aorta. In this report, we describe this underdiagnosed condition in a previously healthy young female presenting with progressive post-prandial emesis, non-specific abdominal pain, and weight loss.

An Allosterically Regulated, Four-State Macrocycle.

Macrocycles capable of host-guest chemistry are an important class of structures that have attracted considerable attention because of their utility in chemical separations, analyte sensing, signal amplification, and drug delivery. The deliberate design and synthesis of such structures are rate-limiting steps in utilizing them for such applications, and coordination-driven supramolecular chemistry has emerged as a promising tool for rapidly making large classes of such systems with attractive molecular recognition capabilities and, in certain cases, catalytic properties. A particularly promising subset of such systems are stimuli-responsive constructs made from hemilabile ligands via the weak-link approach (WLA) to supramolecular coordination chemistry.

Kinetics of the Strain-Promoted Oxidation-Controlled Cycloalkyne-1,2-quinone Cycloaddition: Experimental and Theoretical Studies.

Stimulated by its success in both bioconjugation and surface modification, we studied the strain-promoted oxidation-controlled cycloalkyne-1,2-quinone cycloaddition (SPOCQ) in three ways. First, the second-order rate constants and activation parameters (ΔH) were determined of various cyclooctynes reacting with 4-tert-butyl-1,2-quinone in a SPOCQ reaction, yielding values for ΔH of 4.5, 7.

The crucial role of a spacer material on the efficiency of charge transfer processes in organic donor-acceptor junction solar cells.

Organic photovoltaic donor-acceptor junction devices composed of π-conjugated polymer electron donors (D) and fullerene electron acceptors (A) show greatly increased performance when a spacer material is inserted between the two layers (W. Y. Nie, G.

Structure and electronic states of a graphene double vacancy with an embedded Si dopant.

Silicon represents a common intrinsic impurity in graphene, bonding to either three or four carbon neighbors, respectively, in a single or double carbon vacancy. We investigate the effect of the latter defect (Si-C) on the structural and electronic properties of graphene using density functional theory. Calculations based both on molecular models and with periodic boundary conditions have been performed.

Region-specific glial hyperplasia and neuronal stability of rat lateral geniculate nucleus during aging.

The normal aging process is accompanied by functional declines in image-forming and non-image forming visual systems. Among the components of these systems, the thalamic lateral geniculate nucleus (LGN) offers a good model for aging studies since its three anatomical subdivisions, namely dorsal lateral geniculate nucleus (dLGN), intergeniculate leaflet (IGL) and ventral lateral geniculate nucleus (vLGN), receives light information from retina and projects to different brain areas involved in visual-related functions. Nevertheless, there is very little data available about quantitative morphological aspects in LGN across lifespan.

Post-transition state dynamics and product energy partitioning following thermal excitation of the F⋯HCHCN transition state: Disagreement with experiment.

Born-Oppenheimer direct dynamics simulations were performed to study atomistic details of the F + CHCN → HF + CHCN H-atom abstraction reaction. The simulation trajectories were calculated with a combined M06-2X/MP2 algorithm utilizing the 6-311++G** basis set. The experiments were performed at 300 K, and assuming the accuracy of transition state theory (TST), the trajectories were initiated at the F⋯HCHCN abstraction TS with a 300 K Boltzmann distribution of energy and directed towards products.

Egg donation of vitrified oocytes bank produces similar pregnancy rates by blastocyst transfer when compared to fresh cycle.

Purpose: Advances in reproductive techniques, mainly the introduction of oocyte vitrification, have provided the opportunity to conceive from oocyte banks. The aim of this study was to compare the clinical outcomes of fresh and vitrified oocytes in an egg donation program following blastocyst transfer.

Methods: This retrospective observational study included 504 oocyte donation cycles.

Antitumour activity of resveratrol on human melanoma cells: A possible mechanism related to its interaction with malignant cell telomerase.

Background: trans-Resveratrol (tRES) is a polyphenolic stilbene found in plant products which has attracted great attention because of its antioxidant, anti-inflammatory and anticancer properties.

Methods: The possible correlation between tRES-induced suppression of melanoma cell growth and its influence on telomerase expression has been investigated by biological assays. Moreover, in order to gain new knowledge about possible mechanisms of action of tRES as antineoplastic agent, its interaction with biologically relevant secondary structure-forming DNA sequences, its aggregation properties and copper-binding activity have been studied by CD, UV and fluorescence spectroscopies.

Singlet L and L Bands for N-Acenes (N = 2-7): A CASSCF/CASPT2 Study.

In this work CASPT2 calculations of polyacenes (from naphthalene to heptacene) were performed to find a methodology suitable for calculations of the absorption spectra, in particular of the L (B state) and L (B state) bands, of more extended systems. The effect of the extension of the active space and of freezing σ orbitals was investigated. The MCSCF excitation energy of the B state is not sensitive to the size of the active space used.

Effects of interventions with therapeutic suits (clothing) on impairments and functional limitations of children with cerebral palsy: a systematic review.

Background: Therapeutic suits or clothing whether associated with intensive protocols or not, became popular in the rehabilitation of children with cerebral palsy. Studies have reported positive effects of these suits on children's posture, balance, motor function and gait. A summary of current literature may help guide therapeutic actions.

How to efficiently tune the biradicaloid nature of acenes by chemical doping with boron and nitrogen.

Acenes are fascinating polyaromatic compounds that combine impressive semiconductor properties with an open-shell character by varying their molecular sizes. However, the increasing chemical instabilities related to their biradicaloid structures pose a great challenge for synthetic chemistry. Modifying the π-bond topology through chemical doping allows modulation of the electronic properties of graphene-related materials.

Fluorination of an Alumina Surface: Modeling Aluminum-Fluorine Reaction Mechanisms.

Density functional theory (DFT) calculations were performed to examine exothermic surface chemistry between alumina and four fluorinated, fragmented molecules representing species from decomposing fluoropolymers: F, HF, CHF, and CF. The analysis has strong implications for the reactivity of aluminum (Al) particles passivated by an alumina shell. It was hypothesized that the alumina surface structure could be transformed due to hydrogen bonding effects from the environment that promote surface reactions with fluorinated species.

Isomeric Separation of Permethylated Glycans by Porous Graphitic Carbon (PGC)-LC-MS/MS at High Temperatures.

Permethylation is a common derivatization method for MS-based glycomic analyses. Permethylation enhances glycan ionization efficiency in positive MS analysis and improves glycan structural stability. Recent biological glycomic studies have added to the growing body of knowledge and suggest the need for complete structural analysis of glycans.

Palladium(II) Weak-Link Approach Complexes Bearing Hemilabile N-Heterocyclic Carbene-Thioether Ligands.

A new class of homoligated palladium(II) weak-link approach (WLA) complexes bearing hemilabile N-heterocyclic carbene (NHC)-thioether ligands is reported that, unlike previous tweezer-like WLA complexes, expand and contract in a linear fashion when switching between configurational states. These complexes can be chemically switched between a trans open state and a trans closed state via the addition or subsequent extraction of Cl. These bis(NHC) complexes also display unusual isomerization behavior.

Electronic nature of zwitterionic alkali metal methanides, silanides and germanides - a combined experimental and computational approach.

Zwitterionic group 14 complexes of the alkali metals of formula [C(SiMeOCHCHOMe)M], (M-), [Si(SiMeOCHCHOMe)M], (M-), [Ge(SiMeOCHCHOMe)M], (M-), where M = Li, Na or K, have been prepared, structurally characterized and their electronic nature was investigated by computational methods. Zwitterions M- and M- were synthesized reactions of [Si(SiMeOCHCHOMe)] () and [Ge(SiMeOCHCHOMe)] () with MOBu (M = Li, Na or K), resp., in almost quantitative yields, while M- were prepared from deprotonation of [HC(SiMeOCHCHOMe)] () with LiBu , NaCHPh and KCHPh, resp.

A concerted two-prong approach to the allosteric regulation of bifunctional catalysis.

Herein, we report the reversible "on-off" allosteric regulation of hydrogen-bond-donating (HBD)-Lewis base co-catalytic activity a concerted two-prong methodology entailing cooperative acid-base chemistry and a structurally addressable coordination complex. Specifically, a heteroligated Pt(ii) weak-link approach (WLA) tweezer complex containing both a hemilabile squaramide-piperidine-based catalytic ligand and a sodium sulfonate hydrogen-bond-accepting (HBA) ligand was synthesized. Due to the hemilabile nature of the catalyst-containing ligand, the heteroligated complex can be reversibly toggled between a flexible, semi-open state and a rigid, fully closed state upon the addition of elemental ion cues.

High-level Ab Initio Absorption Spectra Simulations of Neutral, Anionic and Neutral+ Chromophore of Green Fluorescence Protein Chromophore Models in Gas Phase and Solution.

Semiclassical ab initio simulations of the absorption spectra of neutral and anionic p-hydroxybenzylidene-2,3-dimethylimidazolinone (p-HBDI), a model chromophore of green fluorescent protein (GFP) and of a positively charged neutral (N+)-HBDI chromophore model, were performed in gas phase with the resolution-of-identity algebraic diagrammatic construction through second-order (RI-ADC(2)) method. The calculated absorption spectra in gas phase are composed of one band centered at 3.51 eV (HBDI), 2.

Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors.

More than 40 years ago, we discovered that novel transplantation antigens can be induced in vivo or in vitro by treating murine leukemia with dacarbazine. Years later, this phenomenon that we called "Chemical Xenogenization" (CX) and more recently, "Drug-Induced Xenogenization" (DIX), was reproduced by Thierry Boon with a mutagenic/carcinogenic compound (i.e.

Two-Dimensional Gel Electrophoresis: A Reference Protocol.

Two-dimensional gel electrophoresis (2DE) has been a mainstay of proteomic techniques for more than four decades. It was even in use for several years before the term proteomics was actually coined in the early 1990s. Over this time, it has been used in the study of many diseases including cancer, diabetes, heart disease, and psychiatric disorders through the proteomic analysis of body fluids and tissues.

Cation-π interactions in competition with cation microhydration: a theoretical study of alkali metal cation-pyrene complexes.

Cation-π interactions were systematically investigated for the adsorption of H and alkali metal cations M to pyrene by means of Møller-Plesset perturbation theory (MP2) and density functional theory (DFT). The main aims were to determine the preferred adsorption sites and how the microhydration shell influences the adsorption process. The preferred adsorption sites were characterized in terms of structural parameters and energetic stability.