Publications by authors named "Aqiong Chen"
Background: Studies have highlighted a possible crosstalk between the pathogeneses of COVID-19 and systemic lupus erythematosus (SLE); however, the interactive mechanisms remain unclear. We aimed to elucidate the impact of COVID-19 on SLE using clinical information and the underlying mechanisms of both diseases.
Methods: RNA-seq datasets were used to identify shared hub gene signatures between COVID-19 and SLE, while genome-wide association study datasets were used to delineate the interaction mechanisms of the key signaling pathways.
Purpose: This study aimed to compare the changes in the expression of microRNA Let-7i in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and the correlation between Let-7i and innate pro-inflammatory factors. It is necessary to search for a new biomarker to guide the prognosis of AS.
Methods: A total of 10 patients with AS and 10 healthy volunteers were selected as AS and control groups, respectively.
Article Synopsis
- Researchers studied special RNA types called Long noncoding RNAs (lncRNAs) to see how they are related to a disease called systemic lupus erythematosus (SLE).
- They found 143 lncRNAs that were changed in SLE patients, and one of them, called TCONS_00483150, might help tell apart SLE patients from healthy people and those with other diseases.
- The research suggests that TCONS_00483150 may be important for understanding how SLE works and could help doctors diagnose the disease better in the future.
The purpose of this study was to investigate the efficacy of intra-articular injection of infliximab in a rabbit model of osteoarthritis. In 30 New Zealand white rabbits, the cruciate ligaments and medial menisci were resected using the Hulth technique. Eight weeks postsurgery, the animals were randomly divided into three groups, and each group was given monthly intra-articular injections (0.
View Article and Find Full Text PDF