Publications by authors named "Aqian Chang"
Diabetic nephropathy (DN) is the most common microvascular complication of diabetes mellitus and a major cause of end-stage renal disease. Isoferulic acid (IFA) is a phenolic compound that has strong antioxidant, anti-inflammatory, and hypoglycemic effects. Researches and our previous study showed the potential anti-diabetic capacity and anti- oxidative stress damage targeting podocytes of IFA.
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- Immunotherapy for hepatocellular carcinoma (HCC) is limited due to the low immunogenicity of tumors, but strategies like pyroptosis and photothermal therapy can enhance tumor immunogenic cell death (ICD).
- Polyphyllin II (PPII) induces pyroptosis in cancer cells and IR780, activated by laser, generates heat to eliminate them; however, both face challenges like low solubility and poor targeting.
- To improve their effectiveness, PPII and IR780 are co-loaded in targeted PLGA nanoparticles (Apt/PPII/IR780-NPs), allowing for controlled drug release and enhancing anti-tumor immunity, thereby offering a promising new approach for HCC treatment.