Preparation of Tamsulosin Hydrochloride-Loaded Mucoadhesive In Situ Gelling Polymeric Formulation for Nasal Delivery in Geriatrics.

This study aimed to prepare tamsulosin hydrochloride (HCl)-loaded in situ gelling formulation by using hydroxypropyl methylcellulose (HPMC), gellan gum, poloxamer 188, and benzalkonium chloride. Physicochemical evaluation of formulations included determination of pH, viscosity, gelation time, gel strength, drug content, and sterility. In silico study was performed to analyze interactions between polymers, drug, and mucin glycoprotein.

Development and Validation of Facile RP-HPLC Method for Simultaneous Determination of Timolol Maleate, Moxifloxacin Hydrochloride, Diclofenac Sodium and Dexamethasone in Plasma, Aqueous Humor and Pharmaceutical Products.

The present study aimed to develop a validated RP-HPLC method for the simultaneous determination of timolol maleate (TM), moxifloxacin hydrochloride (MOXI), diclofenac sodium (DS) and dexamethasone (DEXA) in human plasma, bovine aqueous humor and pharmaceutical preparations. The chromatographic separation was studied using the C18 column. The chromatographic conditions, such as composition, pH, the flow rate of mobile phase, the temperature of column, wavelength of absorption and injection volume of the sample, were studied.

Nexus on climate change: agriculture and possible solution to cope future climate change stresses.

The changing climate scenarios harshen the biotic stresses including boosting up the population of insect/pest and disease, uplifting weed growth, declining soil beneficial microbes, threaten pollinator, and boosting up abiotic stresses including harsh drought/waterlogging, extremisms in temperature, salinity/alkalinity, abrupt rainfall pattern)) and ulitamtely  affect the plant in multiple ways. This nexus review paper will cover four significant points viz (1) the possible impacts of climate change; as the world already facing the problem of food security, in such crucial period, climatic change severely affects all four dimensions of food security (from production to consumption) and will lead to malnutrition/malnourishment faced by low-income peoples. (2) How some major crops (wheat, cotton, rice, maize, and sugarcane) are affected by stress and their consequent loss.

RP-HPLC based method for the determination of Tamsulosin HCl in API, Prepared dosage form and spiked plasma.

An analytical method for measurement of tamsulosin HCl from its different life cycle stages was developed using RP-HPLC technique. The elution of tamsulsoin was studied using MediterraneaTM Sea 18 column (dimesions 250 × 4.6 mm and pore size 5μm) and mobile phase comprising of buffer (pH 5.

Preparation and characterization of indomethacin loaded films by piezoelectric inkjet printing: a personalized medication approach.

The purpose of this study was to investigate the application of piezoelectric inkjet technology in the preparation of custom-made indomethacin (IMC) films. Indomethacin solutions with and without PVP were printed onto polymeric sheets using a commercial inkjet printer. Drug loading was varied by selecting a machine parameter different dots per inches (DPIs).

Identification of novel in vitro antibacterial action of cloprostenol and evaluation of other non-antibiotics against multi-drug resistant A. baumannii.

A total of 24 non-antibiotic compounds were tested for their antimicrobial activity against Escherichia coli, Klebsiella pneumoniae (ATCC) and an MDR strain of Acinetobacter baumannii using an agar well diffusion assay. To study additive effects, 100 µl of each antibiotic and 50 µl of each non-antibiotic were used. Cloprostenol was the only non-antibiotic that showed antibacterial activity against all bacterial strains.

Evaluation of synergistic antimicrobial effect of vitamins (A, B1, B2, B6, B12, C, D, E and K) with antibiotics against resistant bacterial strains.

Objectives: Multidrug-resistant (MDR) superbugs, including Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA), are a challenge for healthcare professionals. In this study, the synergistic activity of vitamins with antibiotics against resistant bacterial strains was evaluated.

Methods: Synergistic effects between antibiotics and stock solutions of vitamins were evaluated by the Kirby-Bauer disk diffusion assay.