siRNA targeting PARP-1 alleviates diabetic peripheral neuropathy in a streptozotocin-induced rat model.

Diabetic peripheral neuropathy (DPN) is a debilitating complication of diabetes mellitus, affecting nearly 50% of diabetic patients and leading to chronic pain, numbness and progressive sensory and motor function loss. This study investigates the potential of siRNA-mediated silencing of poly(ADP-ribose) polymerase 1 (PARP1) to alleviate DPN in a rat model. PARP1 overactivation, driven by hyperglycaemia-induced oxidative stress, exacerbates neuronal damage in DPN.

Neuroprotective potential of and HPLC analysis of stigmasterol against cisplatin-induced neuropathy in rat model.

Cisplatin is a chemotherapeutic agent known for causing severe peripheral neuropathy as a side effect, impacting patients' quality of life by damaging nerve tissues. This study aims to explore the neuroprotective effects of the ethanolic extract of Roscoe rhizome (EEACR) and stigmasterol identified by high-performance liquid chromatography (HPLC) in a rat model of cisplatin-induced neuropathy. Male Wistar rats were divided into control, cisplatin-induced neuropathic, and two intervention groups receiving different concentrations of EEACR (250 and 500 mg/kg).