Reviewing the potential of probiotics, prebiotics and synbiotics: advancements in treatment of ulcerative colitis.

Inflammatory bowel diseases (IBD) like Crohn's and ulcerative colitis (UC) are multifactorial pathologies caused by environmental factors and genetic background. UC is a chronic inflammatory disorder that specifically targets the colon, resulting in inflammation. Various chemical interventions, including aminosalicylates, corticosteroids, immunomodulators, and biological therapies, have been extensively employed for the purpose of managing symptoms associated with UC.

Assessment of the Apical Transportation and Quantity of Root Canal Dentin Removed Using Different New Rotary File Systems: An Original Study.

Introduction: The rotary systems have found a common application in the clinical practice for the endodontic therapies. Hence, we compared three recent endodontic systems for the comparison of the dentine removal and the apical transportation particularly in the curved canals.

Methods: Oneshape, Pro Taper Next, and Edgefile X3 were the three systems that were compared.

Evaluation of the Root Canal Morphology of Human Teeth by Cone Beam Computed Tomography and Micro-Computed Tomographic - A Systematic Review with Meta-analysis.

Introduction: To thoroughly plan and execute any dental treatment, the anatomy of the dental root canals is of prime significance. Hence, in this systemic review, we intend to evaluate the cone beam computed and micro-computed tomographic presentations of the root canal morphologies of the secondary teeth.

Materials And Methods: We conducted the search for the data from the online sources such as the "EMBASE," "Pubmed," "Scopus," and other sources.

Mannich Bases: Centrality in Cytotoxic Drug Design.

Mannich bases identified by Professor Carl Mannich have been the most extensively explored scaffolds for more than 100 years now. The versatile biological roles that they play have promoted their applications in many clinical conditions. The present review highlights the application of Mannich bases as cytotoxic agents, categorizing them into synthetic, semisynthetic, and prodrugs classes, and gives an exhaustive account of the work reported in the last two decades.