Publications by authors named "Apryl Saunders"
Purpose: G-CSF enhances colon cancer development. This study defines the prevalence and effects of increased G-CSF signaling in human colon cancers and investigates G-CSF inhibition as an immunotherapeutic strategy against metastatic colon cancer.
Experimental Design: Patient samples were used to evaluate G-CSF and G-CSF receptor (G-CSFR) levels by IHC with sera used to measure G-CSF levels.
Article Synopsis
- * The study found higher proportions of CD4+ T cells in women’s tumor and lymph node samples, while CD8+ T cells were more prevalent in their uninvolved colon compared to men.
- * Differential gene expression related to immune functions was observed in women, suggesting that these immune system disparities may explain the survival advantages seen in female CRC patients.
Granulocyte colony-stimulating factor receptor (GCSFR) is a critical regulator of granulopoiesis. Studies have shown significant upregulation of GCSFR in a variety of cancers and cell types and have recognized GCSFR as a cytokine receptor capable of influencing both myeloid and non-myeloid immune cells, supporting pro-tumoral actions. This systematic review aims to summarize the available literature examining the mechanisms that control GCSFR signaling, regulation, and surface expression with emphasis on how these mechanisms may be dysregulated in cancer.
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- * The study focused on colony-stimulating factor 3 (CSF3) and its receptor (CSF3R), analyzing publicly available datasets to explore their roles in colorectal cancer development, and found that their expression correlates with tumor characteristics and poor patient prognosis.
- * Researchers discovered elevated expression of CSF3 and CSF3R in specific molecular subtypes of colorectal cancer, linked to changes in immune cell profiles, particularly T cells and macrophages, suggesting these factors could influence treatment outcomes and disease progression.
Purpose: Glial fibrillary acid protein (GFAP) and vimentin are type III intermediate filament proteins, ubiquitously expressed in retinal glial cells. Under retinal stress, both GFAP and vimentin are well-known sensitive markers for retinal gliosis. However, little is known about whether these proteins are released into the vitreous body in response to retinal gliosis or are related to the severity of retinal gliosis seen in proliferative vitreoretinopathy (PVR).
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