Publications by authors named "Apryl S Saunders"
Purpose: G-CSF enhances colon cancer development. This study defines the prevalence and effects of increased G-CSF signaling in human colon cancers and investigates G-CSF inhibition as an immunotherapeutic strategy against metastatic colon cancer.
Experimental Design: Patient samples were used to evaluate G-CSF and G-CSF receptor (G-CSFR) levels by IHC with sera used to measure G-CSF levels.
Granulocyte colony-stimulating factor receptor (GCSFR) is a critical regulator of granulopoiesis. Studies have shown significant upregulation of GCSFR in a variety of cancers and cell types and have recognized GCSFR as a cytokine receptor capable of influencing both myeloid and non-myeloid immune cells, supporting pro-tumoral actions. This systematic review aims to summarize the available literature examining the mechanisms that control GCSFR signaling, regulation, and surface expression with emphasis on how these mechanisms may be dysregulated in cancer.
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- * The study focused on colony-stimulating factor 3 (CSF3) and its receptor (CSF3R), analyzing publicly available datasets to explore their roles in colorectal cancer development, and found that their expression correlates with tumor characteristics and poor patient prognosis.
- * Researchers discovered elevated expression of CSF3 and CSF3R in specific molecular subtypes of colorectal cancer, linked to changes in immune cell profiles, particularly T cells and macrophages, suggesting these factors could influence treatment outcomes and disease progression.