Publications by authors named "April Fiedler"
Article Synopsis
- Research shows that gut microbiota influences cardiovascular diseases like hypertension and heart failure (HF), with dietary fiber being a significant factor that produces short-chain fatty acids (SCFAs) beneficial for heart health.
- * The study focused on testing if dietary fiber or acetate supplementation could reduce HF development in a genetic mouse model with dilated cardiomyopathy (DCM) due to overexpression of a specific gene (Mst1).
- * Findings indicated that while fiber altered the gut microbiome, it and acetate supplementation did not improve heart condition or prevent heart-related damage in Mst1 mice, highlighting the overpowering role of genetic factors in HF progression.
Background: High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. The impact of lack of prebiotic fiber and the associated mechanisms that lead to higher BP are unknown.
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- The study investigates the role of renal glutathione deficiency in cardiorenal syndrome type 2 by testing N-acetylcysteine (NAC) in mice with dilated cardiomyopathy (DCM).
- Administration of NAC improved various renal parameters, including glomerular filtration rate and levels of fibrosis markers, indicating a protective effect against renal damage.
- The findings suggest that restoring renal oxidized glutathione levels can reduce inflammation and preserve kidney function in cases of DCM.
Article Synopsis
- A high-fiber diet and acetate supplementation were studied to see how they affect gut microbiota and cardiovascular health in mice.
- The high-fiber diet altered gut bacteria composition, reduced blood pressure, and decreased heart and kidney damage compared to a standard diet.
- These beneficial effects were linked to changes in gene expression related to inflammation and cardiovascular regulation, highlighting the protective role of fiber-rich diets against heart disease.