Publications by authors named "Aprajita Tripathi"
Article Synopsis
- - Cadmium (Cd) is a toxic heavy metal that can harm health through inhalation, smoking, or contaminated food, and is linked to chronic lung diseases like COPD and pulmonary fibrosis.
- - A study on C57BL/6 mice showed that exposure to cadmium chloride led to inflammation, increased lung resistance, and changes in immune cell populations, particularly a decrease in CD4 T-cells and an increase in CD8 T-cells.
- - The research highlights the need for more studies to understand how cadmium causes lung damage and immune system disruption, which is vital for finding treatments for lung diseases related to cadmium exposure.
Upon antigenic stimulation, CD4 T-cells undergo clonal expansion, elevating their bioenergetic demands and utilization of nutrients like glucose and glutamine. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a well-known regulator of oxidative stress, but its involvement in modulating the metabolism of CD4 T-cells remains unexplored. Here, we elucidate the role of Nrf2 beyond the traditional antioxidation, in modulating activation-driven expansion of CD4 T-cells by influencing their nutrient metabolism.
View Article and Find Full Text PDFUbiquitously expressed in mammalian cells, the Kelch-like ECH-associated protein 1 (Keap1)-NF erythroid 2-related factor 2 (Nrf2) complex forms the evolutionarily conserved antioxidation system to tackle oxidative stress caused by reactive oxygen species. Reactive oxygen species, generated as byproducts of cellular metabolism, were identified as essential second messengers for T cell signaling, activation, and effector responses. Apart from its traditional role as an antioxidant, a growing body of evidence indicates that Nrf2, tightly regulated by Keap1, modulates immune responses and regulates cellular metabolism.
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