The hidden impact of GLP-1 receptor agonists on endometrial receptivity and implantation.

Increasing infertility rates represent a growing medical challenge in modern societies resulting from a complex interplay of sociocultural trends, lifestyle factors, exposure to environmental toxins, and underlying health problems. Women's fertility is particularly vulnerable to these shifts. The obesogenic lifestyle not only accelerates weight gain, but also disrupts ovulation driving the rise in infertility.

Magnetic Field Effect on the Electric and Dielectric Properties of the Linear Magnetoelectric Compound CoNbO.

Using Green's function theory and a microscopic model, the multiferroic properties of Co4Nb2O9 are investigated theoretically. There are some discrepancies in the discussion of the electric and dielectric behavior of CNO with and without external magnetic fields. We try to clarify them.

Estimation of the digestible energy value of fat obtained from black soldier fly larvae () for growing pigs.

An experiment was conducted to determine the digestible energy (DE) of insect fat (IF) from black soldier fly larvae (BSLF) for growing pigs. Saturated fatty acids (SFA) were the dominant group of fatty acids in the IF, with lauric acid (C12:0) and palmitic acid (C16:0) comprising the greatest concentrations in this group. Linoleic acids (C18:2) and oleic acids (C18:1) were the main unsaturated fatty acids.

Biopsy vitrification: New tool for endometrial tissue cryopreservation for research applications.

Patient-derived endometrial biopsies serve as a crucial source for molecular studies, highlighting the necessity for tissue cryopreservation methods that preserve cell viability and tissue morphology with minimal to no impact. The passive slow freezing (PSF) protocol has demonstrated efficacy for cryopreserving endometrial biopsies, allowing for the subsequent isolation of viable epithelial and stromal cells. Vitrification (VT) enables the avoidance of ice crystal formation and could therefore potentially prevent mechanical injury to tissues.

Multiferroic and Phonon Properties of the Double Perovskite PrFeAlO.

With the help of a microscopic model and Green's function technique, we studied the multiferroic and phonon properties of the recently reported new multiferroic PrFeAlO (PFAO) compound, which belongs to the double perovskite ABB'O family. The magnetization decreases with the increase in temperature and disappears at the ferromagnetic Curie temperature TCFM. The polarization increases with the application of an external magnetic field, indicating strong magnetoelectric coupling and confirming the multiferroic behavior of PFAO.

Theoretical Study of the Multiferroic Properties of Pure and Ion-Doped PbF, = Fe, Cr, Al.

In a first theoretical investigation of the multiferroic properties of Pb5Fe3F19 (PFF) and Pb5Cr3F19 (PCF), we analyze their magnetic, ferroelectric, and dielectric characteristics as functions of temperature, magnetic field, and ion doping concentration using a microscopic model and Green's function theory. The temperature-dependent polarization in PFF and PCF shows a distinctive kink at the magnetic Neel temperature TN, which vanishes when an external magnetic field is applied, indicating the multiferroic behavior of these two compounds. Ion doping effectively tunes the properties of PFF and PCF.

A Theoretical Study of the Effects of Co-Doping Ions at K and Nb Sites on the Properties of KNbO Nanoparticles.

Using a microscopic model and Green's function theory, we have investigated the co-doping effect on ferroelectric KNbO nanoparticles. Let us emphasize that while the doping with transition metal ions at the Nb site leads an increase in the ferromagnetism and a reduction the band gap, it also decreases the ferroelectricity. On the other hand, doping with La or Ba at the K site leads to enhanced polarization, but does not lead to the appearance of ferromagnetism and reduction in the band gap.

Theoretical Study of Co-Doping Effects with Different Ions on the Multiferroic Properties of BiFeO Nanoparticles.

Using a microscopic model and the Green's function theory, the size and co-doping effects on the multiferroic and optical (band gap) properties of BiFeO (BFO) nanoparticles are investigated. The magnetization increases, whereas the band gap energy decreases with decreasing nanoparticle size. The substitution with Co/Mn, Nd/Sm, Ce/Ni, and Cd/Ni is discussed and explained on a microscopic level.

Theoretical Study of the Phonon Energy and Specific Heat of Ion-Doped LiCsSO-Bulk and Nanoparticles.

Using a microscopic model, the temperature dependence of two phonon modes, ω0 = 32 cm and 72 cm, and their damping of the ferroelastic LiCsSO compound, are calculated within Green's function technique. It is observed that the first mode increases whereas the second one decreases with increasing temperature . This different behavior is explained with different sign of the anharmonic spin-phonon interaction constant.

Endometrial Proliferative Phase-Centered View of Transcriptome Dynamics across the Menstrual Cycle.

The endometrium, the inner mucosal lining of the uterus, undergoes complex molecular and cellular changes across the menstrual cycle in preparation for embryo implantation. Transcriptome-wide analyses have mainly been utilized to study endometrial receptivity, the prerequisite for successful implantation, with most studies, so far, comparing the endometrial transcriptomes between (i) secretory and proliferative endometrium or (ii) mid-secretory and early secretory endometrium. In the current study, we provide a complete transcriptome description of the endometrium across the entire menstrual cycle and, for the first time, comprehensively characterize the proliferative phase of the endometrium.

Theoretical Study of the Phonon and Electrical Conductivity Properties of Pure and Sr-Doped LaMnO Thin Films.

The film thickness, temperature, substrate and doping dependence of the phonon energy ω and damping γ, as well as the electrical conductivity, of pure and Sr-doped LaMnO thin films near the phase transition temperature TN are investigated using a microscopic model and the Green's function technique. Due to the strong spin-phonon interaction, there appears a kink at TN in the temperature dependence of ω(T) and γ(T). The softening and hardening of the ω = 495 cm (A) and ω = 614 cm (B) modes is explained by the different sign of the anharmonic spin-phonon interaction constant .

Theoretical Study of the Magnetic and Optical Properties of Ion-Doped LiPO ( = Fe, Ni, Co, Mn).

Using a microscopic model and Green's function theory, we calculated the magnetization and band-gap energy in ion-doped LiPO (LPO), where = Fe, Ni, Co, Mn. Ion doping, such as with Nb, Ti, or Al ions at the Li site, induces weak ferromagnetism in LiFePO. Substituting Li with ions of a smaller radius, such as Nb, Ti, or Al, creates compressive strain, resulting in increased exchange interaction constants and a decreased band-gap energy, Eg, in the doped material.

Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications.

Electronic health records (EHRs) coupled with large-scale biobanks offer great promises to unravel the genetic underpinnings of treatment efficacy. However, medication-induced biomarker trajectories stemming from such records remain poorly studied. Here, we extract clinical and medication prescription data from EHRs and conduct GWAS and rare variant burden tests in the UK Biobank (discovery) and the All of Us program (replication) on ten cardiometabolic drug response outcomes including lipid response to statins, HbA1c response to metformin and blood pressure response to antihypertensives (N = 740-26,669).

Theoretical Study of Electric, Dielectric, and Optical Properties in Ion Doped Multiferroic SrFeO Nanoparticles.

Electric, dielectric, and optical (band gap) properties of pure multiferroic as well as La- and Ni-doped SrFe12O19 (SFO) (at different sites) are investigated using a microscopic model and Green's function technique. The concentration dependence of the polarization is considered for substitution of rare earths ions on the Sr sites. For a small La ion doping concentration, = 0.

Band Gap and Polarization Tuning of Ion-Doped NbO ( = Li, K, Na, Ag) for Photovoltaic and Energy Storage Applications.

Using a microscopic model and Green's function theory, we have calculated the band gap energy and the polarization of LiNbO, KNbO, AgNbO, and NaNbO. The effects by substitution of different ions at A or/and B sites for doping concentration = 0-0.1 are studied.

Origin of Multiferroism in VOX (X = Cl, Br, I) Monolayers.

Based on the proposed microscopic model, we investigate the multiferroic characteristics of VOX (X = Cl, Br, I) monolayers using a Green's function method. The dependence of the microscopic parameters of the ferroelectric system (pseudo-spin arrangement and flipping rate) on the magnitude and sign of the exchange magnetic interaction along the -axis and the value of the Dzyaloshinskii-Moria vector have been investigated and qualitatively explained. The possibility of observing a spin-reorientation transition with a change in the character of spin ordering from antiferromagnetic to ferromagnetic is investigated.

Multiferroic Properties of Co, Ru, and La Ion Doped KBiFeO.

The magnetic, electric, dielectric, and optical (band gap) properties of ion doped multiferroic KBiFe2O5 (KBFO) have been systematically investigated utilizing a microscopic model and the Green's function theory. Doping with Co at the Fe site and Ru at the Bi site induces changes in magnetization, coercive field, and band gap energy. Specifically, an increase in magnetization is observed, while the coercive field and band gap energy decrease.

Postbiotics Production of Candidate-Probiotic AC131 with Renewable Bio Resources.

is a versatile specie, well known as a producer of lactic acid (LA) and other metabolites with biotechnological significance. The present work characterizes growth and lactic acid production of the candidate-probiotic strain AC131, from Bulgarian white brined cheeses. Different nutritional media with ingredients from renewable resources-reduced sugars from dried distillers' grains with soluble (DDGS) and waste waters from the water-vapor distillation of Bulgarian L.

Poly(acrylic acid-co-acrylamide)/Polyacrylamide pIPNs/Magnetite Composite Hydrogels: Synthesis and Characterization.

Novel composite hydrogels based on poly(acrylic acid-co-acrylamide)/polyacrylamide pseudo-interpenetrating polymer networks (pIPNs) and magnetite were prepared via in situ precipitation of Fe/Fe ions within the hydrogel structure. The magnetite formation was confirmed by X-ray diffraction, and the size of the magnetite crystallites was shown to depend on the hydrogel composition: the crystallinity of the magnetite particles increased in line with PAAM content within the composition of the pIPNs. The Fourier transform infrared spectroscopy revealed an interaction between the hydrogel matrix, via the carboxylic groups of polyacrylic acid, and Fe ions, which strongly influenced the formation of the magnetite articles.

Magnetic, Optical and Phonon Properties of Ion-Doped MgO Nanoparticles. Application for Magnetic Hyperthermia.

The influence of size and doping effects on the magnetization , phonon ω and band gap energy Eg of MgO nanoparticles is studied using a microscopic model. The room-temperature ferromagnetism is due to surface or/and doping effects in MgO nanoparticles (NPs). The influence of the spin-phonon interaction is discussed.

The Dynamics of miR-449a/c Expression during Uterine Cycles Are Associated with Endometrial Development.

The human endometrium is a highly dynamic tissue. Increasing evidence has shown that microRNAs (miRs) play essential roles in human endometrium development. Our previous assay, based on small RNA-sequencing (sRNA-seq) indicated the complexity and dynamics of numerous sequence variants of miRs (isomiRs) that can act together to control genes of functional relevance to the receptive endometrium (RE).

Band Gap Tuning in Transition Metal and Rare-Earth-Ion-Doped TiO, CeO, and SnO Nanoparticles.

The energy gap Eg between the valence and conduction bands is a key characteristic of semiconductors. Semiconductors, such as TiO2, SnO2, and CeO2 have a relatively wide band gap Eg that only allows the material to absorb UV light. Using the s-d microscopic model and the Green's function method, we have shown two possibilities to reduce the band-gap energy Eg-reducing the NP size and/or ion doping with transition metals (Co, Fe, Mn, and Cu) or rare earth (Sm, Tb, and Er) ions.

Magnetic, Phonon and Optical Properties of Transition Metal and Rare Earth Ion Doped ZnS Nanoparticles.

The surface, size and ion doping effects on the magnetic, phonon and optical properties of ZnS nanoparticles are studied based on the s-d model including spin-phonon and Coulomb interaction, and using a Green's function theory. The changes of the properties are explained on a microscopic level, due to the different radii between the doping and host ions, which cause different strains-compressive or tensile, and change the exchange interaction constants in our model. The magnetization increases with increasing small transition metal (TM) and rare earth (RE) doping concentration.

Polyacrylamide/poly(2-(dimethylamino) Ethyl Methacrylate) Interpenetrating Polymer Networks as Drug Delivery Systems for Diclofenac Sodium.

Nowadays, modern pharmaceutical investigations are directed toward the design and production of drug delivery systems for achieving prolonged and controlled drug delivery. In this respect, the use of interpenetrating polymer networks (IPNs) is an opportunity in the preparation of polymer drug delivery systems with desired characteristics. This paper describes the synthesis and characterization of novel poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) and polyacrylamide (PAAm)-based IPNs with different compositions and their application as diclofenac sodium delivery systems.