Publications by authors named "Apostolos Agrafiotis"

Introduction: Uniportal video-assisted thoracoscopic surgery (uVATS) is becoming popular for major lung resections, even for more complex procedures. The technique initially described for minor procedures seems more difficult to reproduce and has a longer learning curve. This review aims to describe the evolution from multiportal to uVATS and to explore its feasibility and reproducibility by identifying its drawbacks and limitations.

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  • Thymic epithelial tumors (TETs) are rare tumors found in the chest and include types like thymomas and thymic carcinomas.
  • The best way to treat these tumors is usually through surgery, but there's disagreement about the best method to perform the surgery.
  • New techniques like video-assisted and robotic surgeries are becoming popular, especially for early-stage TETs, but more research is needed to see how they compare in the long term to traditional surgery methods.
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  • The study investigates the impact of the number of involved structures (NIS) on the prognosis of patients with thymic epithelial tumors (TETs) who underwent surgery, using data from the European Society of Thoracic Surgeons (ESTS) thymic database.
  • Out of 303 patients analyzed, those with more than two involved structures had significantly worse cancer-specific survival (CSS) compared to those with two or fewer, with 5-year CSS rates of 9.5% versus 93.2%, respectively.
  • Factors such as neoadjuvant therapy, complete resection, and thymoma histology were associated with better prognosis, highlighting the importance of NIS in determining patient outcomes.
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Background: Postoperative pneumonia (POP) is a hospital acquired pneumonia that occurs >48 hours after tracheal intubation. The diagnosis of POP should be based on clinical and radiological findings within 30 days after surgery. It is a common complication after thoracoscopic surgery for lung cancer patients.

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Angiogenesis significantly influences the carcinogenesis of thymic epithelial tumors (TET). Both thymomas and thymic carcinoma (TC) overexpress VEGF-A and VEGFR-1 and -2. This review aims to provide an appraisal of the use of anti-angiogenics in the treatment of TET.

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Background: Thymic epithelial tumors (TET) are rare neoplasms of the anterior mediastinum. Surgery is the mainstay treatment for resectable TET, whereas systemic treatments are reserved for unresectable and metastatic tumors. The development of new treatments, such as immune checkpoint inhibitors (ICI) and targeted therapies, with promising results in other types of solid tumors, has led to the investigation of their potential efficacy in TET.

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The tumor microenvironment (TME) is a complex and constantly changing entity. The TME consists of stromal cells, fibroblasts, endothelial cells, and innate and adaptive immune cells. Cancer development and progression occurs through this interplay between the tumor and the adjacent stroma.

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  • Liver transplantation can lead to chest complications due to the liver's proximity to the diaphragm and the effects of chronic liver disease on lung function.
  • The review focuses on identifying chest complications during and after liver transplantation that may require invasive procedures or surgical interventions.
  • A collaborative approach among abdominal surgeons, ICU physicians, and thoracic surgeons is essential for early recognition and treatment of these complications.
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Thymic epithelial tumors (TET) are a group of rare neoplasms of the anterior mediastinum comprising thymomas and thymic carcinomas. The carcinogenesis of TET is mostly unknown. Many studies, mostly retrospective case series, have tried to establish prognostic factors in TET.

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Background: E-learning has become an important tool in surgical education in the last decade. The European Society of Thoracic Surgeons launched its e-learning platform in 2013 and started its educational webinars series in 2018. The aim of this paper is to discuss the introduction, evolution and impact of the educational webinars within this e-learning platform.

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Background: There are studies showing the utility of the 18-fluorodeoxyglucose positron emission tomography (FDG PET) scan in the management of patients with thymic epithelial tumors. It seems to be a correlation between the standard uptake value (SUVmax) of thymic epithelial tumors and the histological type and the stage. This study aims to use the ratio of the SUVmax of the lesion to the SUVmax of the adjacent mediastinal tissues in order to guide the choice of the surgical access.

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Thymic cysts are rare lesions (1-5% of all mediastinal masses) and, most of the times, are incidental findings. The coexistence of a lymphoma and a thymic cyst is rare. In the case reported herein, microscopic foci of a diffuse large B-cell lymphoma were identified in the wall of a resected thymic cyst.

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Background: Cases of spontaneous pneumothorax have been described in patients suffering from coronavirus disease 2019 (COVID-19) pneumonia. The aim of this study is to systematically review all the cases of spontaneous pneumothorax that occurred in healthy patients with no underlying lung disease and who did not receive invasive mechanical ventilation.

Methods: A PubMed research was conducted.

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Postoperative chylothorax is the most frequent cause of traumatic thoracic chyle leakage. Conservative treatment is primarily used to treat low flow rate chylothoraces and should be initiated as soon as the diagnosis has been made. In case of high flow rate chylothorax or failure of initial treatment, surgery and radiological treatment are indicated.

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was first identified in 1995. To the best of our knowledge, pleural empyema caused by has never been reported. In the case reported herein, a patient with pleural empyema was treated surgically, and in the bacterial samples, was isolated.

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Background: Double coronary artery is a rare anomaly with just a few cases reported in the literature. This anomaly started being reported recently with the wide use of coronary angiography. Before the advent of advanced imaging and catheterization facilities most of the available data came from the work of anatomists.

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  • The study aimed to compare postoperative outcomes in patients aged under and over 65 who underwent rib fixation, focusing on various health metrics.
  • Results showed no significant differences in injury severity, surgery indications, and mortality rates between age groups, but elderly patients had higher instances of cognitive complications.
  • Elderly patients also experienced longer hospital stays post-surgery, highlighting a need for tailored care despite similar overall outcomes to younger patients.
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Introduction: Pulmonary Sclerosing Pneumocytoma (PSP) is a rare type of benign lung tumor usually encountered in middle-aged Asian women. The lesion is mostly found on routine chest x-rays. Though surgery is recognized as the recommended treatment, there is no consensus on the standard operative procedure for this tumor.

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Introduction: Spontaneous pneumothorax occurs rarely during pregnancy with less than 100 cases reported in the English literature. There is no strong evidence concerning the treatment of spontaneous pneumothorax during pregnancy and labor. The aim of this study is to systematically review all the reported cases and to suggest recommendations for its diagnosis and treatment.

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Introduction: There is no data regarding the incidence and treatment of deep infection affecting the surgical implants after rib fixation. The aim of this study is to share our experience in the management of infected material after surgical rib fixation.

Methods: The medical records of operated patients from January 2012 to December 2018 were retrospectively analyzed.

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