Tumor budding is associated with poor prognosis and clinicopathologic factors in esophageal carcinoma: A meta-analysis.

Background And Objective: Tumor budding is associated with the prognosis of several solid cancers, but further evidence is needed to identify its relation with esophageal cancer. Our study aims to assess the relationship between tumor budding and overall survival, disease-free survival, and clinicopathologic variables in EC.

Methods: Multiple electronic databases were searched and 20 relevant studies containing 3370 patients were identified.