Inhibition of cell proliferation and migration by extracts on breast cancer cells via Rac1 modulation.

In this study, we investigated how leaf and fruit extracts affect the viability and migration of MCF-7 breast cancer cells and the mechanisms of action responsible for these effects. MCF-7 cells treated with the extracts were examined using the sulforhodamine B, colony formation and caspase 3 activity assays, and by Western blotting. extracts were found to inhibit MCF-7 cell growth in a concentration- and time-dependent manner, with 48 h IC values of 57.