Minimally invasive bipolar fractional radiofrequency treatment upregulates anti-senescence pathways.

Background: The sirtuin gene family has been implicated in various anti-senescence pathways. Its connection, if any, with the skin wound healing response has yet to be elucidated.

Objective: The goal of our study was to better understand the effects of FRF treatment on the sirtuin anti-senescence pathway in skin.