Publications by authors named "Aparna Ram"
Article Synopsis
- DNA methylation changes in autosomal dominant polycystic kidney disease (ADPKD) present a new treatment target, but the combination of DNA methylation inhibitors and ADPKD drugs like metformin and tolvaptan hasn't been thoroughly studied.* !
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- Researchers tested the combination of these drugs in 2D and 3D cystic kidney cells, discovering that the DNA methylation inhibitor 5-aza-2'-deoxycytidine (Aza) works well with metformin to lower cell growth and viability.* !
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- The study found significant changes in global methylation patterns, with hypomethylation at genes related to ADPKD and cancer, suggesting potential for improved treatments
