Link between gut damage and neurotoxicity with gender differences in zebrafish: Dibutyl phthalate-driven microbiota dysbiosis as a possible major cause.

Among plasticizers, dibutyl phthalate (DBP) is widely used in in industry, posing significant health risks to aquatic organisms. In this study, adult male and female zebrafish were exposed to 0 and 30 μg/L DBP for 15 days. Behavioral monitoring, immunofluorescence, protein immunoblotting, and high-throughput sequencing were used to investigate the critical role of the gut microbiome in DBP-induced dysfunction of the zebrafish gut-brain axis.

Genome-wide analysis of KCS genes in tomato and functional characterization of SlKCS8 and SlKCS10 in drought tolerance.

KCS, an endogenous cellular enzyme, catalyzes the elongation of fatty acid chains and plays a crucial role in the biosynthesis of plant epidermal wax. Through processes such as transfer, decarboxylation, and fixation, it contributes to plant growth and adaptation to abiotic and biotic stresses. However, the mechanism by which KCS genes participate in the response of tomato plants to driught remains unclear.

Identification of the small auxin up-regulated RNA in tomato and investigation of SlSAUR50 as a positive regulator of tomato resistance to Botrytis cinerea.

The indole-3-acetic acid (IAA) signaling pathway plays a critical role in plant growth, development, and stress responses. Botrytis cinerea is a major biotic stress factor affecting tomato production. However, the mechanism by which small auxin up-regulated RNA (SAUR) genes participate in the response of tomato plants to B.

Electron Transfer-Driven Nanozymes Boost Biosensor Sensitivity via a Synergistic Signal Amplification Strategy.

The conventional gold nanoparticles (AuNPs) with insufficient brightness face substantial challenges in developing a sensitive lateral flow immunoassay (LFIA). Herein, multibranched manganese-gold (Mn-Au) nanoparticles (MnAuNPs) with a Au core-Mn shell nanostructure were synthesized by a one-pot method. The Mn shell of valence-rich and Au core of high electron transfer efficiency endowed MnAuNPs with oxidase-like activity, which oxidized 3,3',5,5'-tetramethylbenzidine (TMB) only by electron transfer.

Metabolomics and Transcriptomics Reveal the Role of the Terpene Biosynthetic Pathway in the Mechanism of Insect Resistance in .

Terpenes are a large variety of natural organic compounds that can enhance the resistance of plants to phytophagous insects through induction. In this study, differential expression genes and metabolites of (AC) and (SH) were screened and analyzed by transcriptomics and metabolomics. The results show that terpene biosynthesis is one of the most crucial secondary metabolic pathways in plants.

Case Report: Severe ophiasis-pattern alopecia areata with concomitant atopic dermatitis in a 5-year-old boy successfully treated with dupilumab.

Alopecia areata (AA) is the third most common reason for dermatological consultations among children. Despite the availability of numerous therapies for AA, including topical and systemic modalities, management options for children diagnosed with severe AA are limited due to the lack of safe and effective treatments suitable for long-term use. Herein, a case involving a 5-year-old boy with severe ophiasis-pattern AA and moderate atopic dermatitis (AD), who was successfully treated with dupilumab, is reported.

A first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy.

Despite significant advancements in kinase-targeted therapy, the emergence of acquired drug resistance to targets such as KRAS and MEK remains a challenge. Extracellular-regulated kinase 1/2 (ERK1/2), positioned at the terminus of this pathway, is highly conserved and less susceptible to mutations, thereby garnering attention as a crucial therapeutical target. However, attempts to use monotherapies that target ERK1/2 have achieved only limited clinical success, mainly due to the issues of limited efficacy and the emergence of drug resistance.

Discovery of 3-indolylbenzoquinone derivatives with therapeutic potential for breast cancer.

Breast cancer is one of the most prevalent malignant tumors in women, but the side effects and drug resistance limit the long-term effectiveness of existing drugs. To address these issues, we designed and synthesized a series of novel mono- and bis-indole-substituted 3-indolylbenzoquinone derivatives and evaluated their inhibitory activity against breast cancer. Among them, compound 1b demonstrated the most potent inhibitory activity against the MDA-MB-231 breast cancer cell line (IC = 3.

QSAR modeling on aromatase inhibitory activity of 23 triazole fungicides by tritium-water release assay.

The 1,2,4-triazole fungicides are extensively used in agriculture, and their impacts on aquatic organisms by continuous release are increasingly concerned. Aromatase, a rate-limiting enzyme for androgens converting to estrogens, is considered as a potential target for triazole fungicides. To reveal and predict the aromatase inhibition capacity of the existing and future developed triazole fungicides, 23 commonly used 1,2,4-triazole fungicides were used for the evaluation of their inhibitory effects (expressed as the 50% inhibitory concentration (IC)) on human aromatase by H-HO release assay in the present study.

Identifying potential drug targets for seborrheic keratosis through druggable genome-wide Mendelian randomization and colocalization analysis.

Seborrheic keratosis (SK) is the most prevalent benign epidermal tumor in adults, characterized by complex pathogenesis and diverse clinical subtypes. This study systematically evaluated the genetic susceptibility and identified novel therapeutic targets for SK. We applied two-sample Mendelian randomization (MR) using cis-eQTL data for druggable genes in blood and SK genome-wide association study (GWAS) data to identify causal genes.

Mitophagy in Neurodegenerative Diseases: Mechanisms of Action and the Advances of Drug Discovery.

Neurodegenerative diseases (NDDs), such as Parkinson's disease (PD) and Alzheimer's disease (AD), are devastating brain diseases and are incurable at the moment. Increasing evidence indicates that NDDs are associated with mitochondrial dysfunction. Mitophagy removes defective or redundant mitochondria to maintain cell homeostasis, whereas deficient mitophagy accelerates the accumulation of damaged mitochondria to mediate the pathologies of NDDs.

Synthesis of SnO₂/COF Green Nanomaterials for Effective Pesticide Decomposition and Promoting Tomato Plants Growth.

In last few decades, the agriculture sector is facing various type of crops diseases originated by crop pests. Among various crops the tomato plant is greatly affected by many pests such as aphids and whiteflies, which are badly decreasing tomato plant yield and effecting its growth. In last few years, various type of pesticides such as Neonicotinoids and Pyrethroids are employed which are badly effecting eco-system and water bodies.

Identifying a Biocontrol Bacterium with Disease-Prevention Potential and Employing It as a Powerful Biocontrol Agent Against .

Biocontrol microbes are environment friendly and safe for humans and animals. To seek biocontrol microbes effective in suppressing is important for tomato production. is a soil-borne pathogen capable of causing wilt in numerous plant species.

Chromosome-level genome assembly of Cyperus iria, an aggressive weed of rice.

Cyperus iria is an aggressive weed of rice throughout the world. Until now, the reference genome of C. iria has not been published.

Chlorpyrifos Influences Tadpole Development by Disrupting Thyroid Hormone Signaling Pathways.

Chlorpyrifos (CPF) is a widely used organophosphate insecticide with serious toxicological effects on aquatic animals. Although extensively studied for neurotoxicity and endocrine disruption, its stage-specific effects on amphibian metamorphosis and receptor-level interactions remain unclear. This study investigated the effects of CPF on metamorphosis at environmentally relevant concentrations (1.

Four-Dimensional Data-Independent Acquisition-Based Proteomic Profiling Combined with Transcriptomic Analysis Reveals the Involvement of the Slym1-SlFHY3-CAB3C Module in Regulating Tomato Leaf Color.

In green plants, the chloroplast is responsible for light energy transition and organic assimilation. However, the molecular mechanisms underlying chloroplast development in horticultural crops remain unclear. Here, four-dimensional data-independent acquisition-based proteomic profiling identified 1,727 differentially expressed proteins between "Zhongshu 4" (ZS4) and () leaves, a considerable proportion of which were down-regulated chloroplast proteins.

Successful treatment of SAPHO syndrome with oral abrocitinib: a case report.

Aim: SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a rare autoimmune disorder characterized by typical cutaneous lesions (palmoplantar pustulosis and eruptive acne) and osteoarticular symptoms (aseptic osteomyelitis and joint inflammation). This study aims to evaluate the therapeutic efficacy and safety of Janus kinase 1 (JAK1) inhibitor abrocitinib in patients with SAPHO syndrome.

Methods: We presented a patient with SAPHO syndrome with accelerated disease progression who did not respond to traditional therapies.

Factors associated with comorbidity development in atopic dermatitis: a cross-section study.

Identifying the characteristics of atopic dermatitis (AD) patients with its comorbidity has become increasingly crucial. We aimed to investigate the relevant factors associated with comorbidities in adults with AD. We analyzed cross-sectional data through univariate and multivariate regression analyses, encompassing 439 adult cases of AD from the Clinical Research and Homogenization Diagnosis and Treatment Project for Type 2 Inflammatory Dermatosis.

Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing.

Background: Skin wound healing involves a complex gene expression programme that remains largely undiscovered in humans. Circular RNAs (circRNAs) and microRNAs (miRNAs) are key players in this process.

Objectives: To understand the functions and potential interactions of circRNAs and miRNAs in human skin wound healing.

Enhanced remediation of real agricultural runoff in surface-flow constructed wetlands by coupling composite substrate-packed bio-balls, submerged plants and functional bacteria: Performance and mechanisms.

Import of agricultural runoff containing nutrients considerably contributes to eutrophication of receiving water bodies. Surface-flow constructed wetlands (SFCWs) are commonly applied for agricultural runoff purification, but the performance is usually unsatisfactory. In this study, suspended bio-balls filled with zeolite and iron-carbon (Fe-C) composite substrates, submerged macrophyte (Ceratophyllum demersum) and functional denitrifying bacteria were collectively added into SFCW microcosms to enhance the remediation efficiency for real agricultural runoff with high nutrient concentrations and low content of bioavailable organic matter.

Selective Covalent Inhibiting JNK3 by Small Molecules for Parkinson's Diseases.

c-Jun N-terminal kinases (JNKs) including JNK1/2/3 are key members of mitogen-activated protein kinase family. Wherein JNK3 is specifically expressed in brain and emerges as therapeutic target, especially for neurodegenerative diseases. However, developing JNK3 selective inhibitors as chemical probes to investigate its therapeutic potential in diseases remains challenging.