Publications by authors named "Aoxi Tian"
Background: Evidence of socioeconomic status (SES)-related health inequality is scarce in patients with cardiovascular diseases (CVDs) who need both lifestyle change and medical care, particularly in developing countries.
Methods: The study employed a nationwide population-based cohort design, covering all 31 provinces of Chinese mainland from September 2014 to March 2021. Participants aged 35-75 years with self-reported CVD diagnoses were included.
Article Synopsis
- Increased leisure-time physical activity (LTPA) is beneficial as it reduces mortality risk, but may also lead to left ventricular hypertrophy (LVH), prompting research into how LVH impacts the mortality benefits of LTPA in those with high cardiovascular risk.* -
- The study analyzed data from over 163,000 participants, finding that those with moderate to high LTPA had lower risks of cardiovascular and all-cause mortality compared to low LTPA, particularly in individuals without LVH.* -
- While high LTPA continued to show a protective benefit against all-cause mortality in participants with LVH, the overall impact of LVH differed in its relation to mortality risk, indicating that LVH did
Article Synopsis
- The study explores the characteristics and outcomes of patients with STEMI in China who lack standard modifiable cardiovascular risk factors (SMuRFs).
- Patients without SMuRFs were typically older, had more severe health issues upon admission, and received less aggressive treatment compared to those with SMuRFs.
- The findings revealed a significantly higher in-hospital mortality rate for SMuRF-less patients, indicating a need for improved medical management and understanding of their unique health challenges.
Background: Heart failure with preserved ejection fraction is a major global public health problem, while effective risk stratification tools are still lacking. We sought to construct a multi-mRNA signature to predict 1-year all-cause death.
Methods: We selected 30 patients with heart failure with preserved ejection fraction who died during 1-year follow-up and 30 who survived in the discovery set.
Cognitive impairment in young and middle-aged patients with acute heart failure.
ESC Heart Fail
October 2024
Article Synopsis
- The study aimed to explore how common cognitive impairment is in young and middle-aged patients with acute heart failure (HF) and identify its risk factors and effects on health outcomes.
- Among 1,958 participants, 19.6% showed signs of cognitive impairment, with older age, female gender, lower education levels, and previous strokes as key predictors.
- The presence of cognitive impairment increased the risk of cardiovascular death or HF rehospitalization within 30 days but did not significantly impact the one-year outcomes, highlighting the need for early screening and intervention strategies for at-risk patients.
Objective: Home blood pressure monitoring (HBPM) is viewed as a facilitating factor in the initial diagnosis and long-term management of treated hypertension. However, evidence remains scarce about the effectiveness of HBPM use in the real world. This study aimed to examine the associations of HBPM use with blood pressure (BP) control and medication adherence.
View Article and Find Full Text PDFBackground And Aim: Left ventricular hypertrophy (LVH) has been shown to be associated with the occurrence of atrial fibrillation (AF). However, the predictive value of the LVH phenotype for incident AF remains uncertain. This study aimed to investigate the predictive value of LVH phenotype for incident AF.
View Article and Find Full Text PDFBackground Knowledge gaps remain in how gender-related socioeconomic inequality affects sex disparities in cardiovascular diseases (CVD) prevention and outcome. Methods and Results Based on a nationwide population cohort, we enrolled 3 737 036 residents aged 35 to 75 years (2014-2021). Age-standardized sex differences and the effect of gender-related socioeconomic inequality (Gender Inequality Index) on sex disparities were explored in 9 CVD prevention indicators.
View Article and Find Full Text PDFBackground Elevated hsCRP (high-sensitivity C-reactive protein) level is associated with worse prognosis among patients hospitalized for heart failure. However, the prognostic value of the long-term cumulative hsCRP remains unknown. Methods and Results We consecutively enrolled patients hospitalized for heart failure and collected their hsCRP data at admission and 1 and 12 months after discharge.
View Article and Find Full Text PDFBackground: The chronic effects of fine particulate matter (PM) at high concentrations remains uncertain. We aimed to examine the relationship of long-term PM exposure with all-cause and the top three causes of death (cardiovascular disease [CVD], cancer, and respiratory disease), and to analyze their concentration-response functions over a wide range of concentrations.
Methods: We enrolled community residents aged 35-75 years from 2014 to 2017 from all 31 provinces of the Chinese Mainland, and followed them up until 2021.
Article Synopsis
- Patients with acute heart failure (AHF) and residual congestion who also have renal dysfunction face poor clinical outcomes, leading researchers to propose a new indicator called the congestion and renal index (CRI).
- The study involved 944 AHF patients, measuring their thoracic fluid content relative to kidney function before discharge, to see how CRI correlated with outcomes over one year.
- Results showed that a higher CRI indicated a greater risk of cardiovascular death or hospitalization, proving that CRI adds valuable prognostic information beyond existing scoring systems.
Background Improving health status is one of the major goals in the management of heart failure (HF). However, little is known about the long-term individual trajectories of health status in patients with acute HF after discharge. Methods and Results We enrolled 2328 patients hospitalized for HF from 51 hospitals prospectively and measured their health status via the Kansas City Cardiomyopathy Questionnaire-12 at admission and 1, 6, and 12 months after discharge, respectively.
View Article and Find Full Text PDFBackground The age-related trends in the predictive ability of carotid intima-media thickness (CIMT) for cardiovascular risk remain unclear. We aimed to identify the age-related trends in the predictive value of CIMT for cardiovascular death. Methods and Results In a prospective cohort of adults aged 35 to 75 years without history of cardiovascular disease who were enrolled between 2014 and 2020, we measured CIMT at baseline and collected the vital status and cause of death.
View Article and Find Full Text PDFAims: This study aimed to evaluate the cumulative high-sensitivity cardiac troponin T (hs-cTNT) from admission to 12 months after discharge and its association with mortality after 12 months among patients with acute heart failure (HF).
Methods: We used data from the China Patient-Centered Evaluative Assessment of Cardiac Events Prospective Heart Failure Study (China PEACE 5p-HF Study), which enrolled patients hospitalized primarily for HF from 52 hospitals between 2016 and 2018. We included patients who survived within 12 months and had hs-cTNT data at admission (within 48 h of admission) and 1 and 12 months after discharge.
Background: Physical activity (PA) is an important component of secondary prevention after myocardial infarction (MI). The mortality risk of MI survivors varies at different post-MI periods, yet the time-varying effect of total PA is unclear. We aimed to investigate the association between different volumes and patterns of total PA and mortality at different post-MI periods.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed the cognitive function of 2,307 heart failure patients both before discharge and one month later, revealing that 13.8% developed new-onset cognitive impairment post-discharge.
- Among those with cognitive impairment, nearly half experienced transient issues, while the other half faced persistent impairment.
- Patients with new-onset cognitive impairment showed a higher risk of cardiovascular death or hospital readmission, emphasizing the need for monitoring cognitive health, especially in patients identified as high-risk.
Background: Inflammation contributes to the progression of heart failure (HF). However, long-term inflammatory trajectories and their associations with outcomes in patients with acute HF remain unclear.
Methods: Data was obtained from the China Patient-Centered Evaluative Assessment of Cardiac Events Prospective Heart Failure Study, and high-sensitivity C-reactive protein (hsCRP) was used to reflect the inflammatory level.
Article Synopsis
- A rising number of patients in hospitals with heart failure (HF) are diagnosed with HF with preserved ejection fraction (HFpEF), prompting research into effective prognostic biomarkers like growth differentiation factor 15 (GDF-15).
- This study evaluated serum GDF-15 levels in 380 hospitalized HFpEF patients to predict their risk of death and heart failure readmission within one year, finding significant correlations.
- GDF-15 showed better predictive accuracy for outcomes compared to the existing NT-proBNP model, indicating its potential as a valuable biomarker for managing HFpEF in clinical settings.
Background The patterns of depressive symptom change during the first month after discharge, as well as their prognostic implications, and predictors of persistent or new-onset depressive symptoms are not well characterized. Methods and Results We included patients hospitalized for heart failure undergoing Patient Health Questionnaire-2 before discharge and at 1 month after discharge in a multicenter prospective cohort. We characterized 4 patterns of change in depressive symptoms-persistent, new-onset, remitted depressive symptoms, and no depressive symptom-and examined the associations between the 4 patterns and 1-year clinical outcomes.
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- High systolic blood pressure (SBP) is linked to poor health outcomes in patients with heart failure (HF), and this study aimed to clarify how SBP affects long-term prognosis for those hospitalized with HF.
- Researchers included 4,564 adult patients from 52 hospitals in China and assessed SBP at discharge, tracking rates of 1-year all-cause death and HF readmission.
- Results showed that SBP levels below 110 mmHg and above 150 mmHg significantly increased risks for both death and readmission, indicating a J-curve relationship with optimal SBP around 130 mmHg.
Background And Aims: Familial hypercholesterolemia (FH) is a genetic disorder with a high burden of arteriosclerotic cardiovascular disease. The prevalence of heterozygous FH is currently 0.2%-0.
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- Heart failure with preserved ejection fraction (HFpEF) is a significant public health issue that lacks effective ways to assess patient risk.
- The study analyzed 18 biomarkers in 380 hospitalized patients to predict the 2-year risk of all-cause death, using techniques like Cox regression and a machine learning method called support vector machine (SVM).
- Results showed that certain biomarkers can effectively predict mortality risk, and the SVM model significantly improved patient classification over traditional methods, indicating its potential for better risk assessment in HFpEF.
Objectives: This study aims to examine the association between the Kansas City Cardiomyopathy Questionnaire (KCCQ)-12 score and the 30-day and 1-year rates of composite events of cardiovascular death and heart failure (HF) rehospitalization in patients with acute HF.
Background: Few studies reported the prognostic effects of KCCQ in acute HF.
Methods: This study prospectively enrolled adult patients hospitalized for HF from 52 hospitals in China and collected the KCCQ-12 score within 48 hour of index admission.
Article Synopsis
- The study aimed to explore the link between admission systolic blood pressure (SBP) and one-year outcomes in heart failure patients hospitalized in China.
- It analyzed data from nearly 4,900 patients and found that lower admission SBP was linked to higher risks of both all-cause death and heart failure readmission, particularly when SBP was below 120 mmHg.
- These findings suggest that monitoring and managing admission SBP could be crucial for improving the prognosis of heart failure patients after hospitalization.
Background: The health effects of air pollution on heart failure (HF) patients have not been adequately studied.
Objectives: We assessed the associations between long-term air pollution exposure and prognosis in HF patients.
Methods: HF patients were prospectively recruited from 52 hospitals throughout China between August 2016 and May 2018.