Publications by authors named "Aowei Xie"
Article Synopsis
- Glutathione peroxidase 4 (GPX4) is essential in the ferroptosis pathway, presenting a promising target for treating difficult tumors, but current inhibitors lack effectiveness and selectivity.
- Researchers developed potent anti-GPX4 nanobodies using Bactrian camels and a phage library, improving their ability to target GPX4 in cells.
- The nanobody 12E showed significant anti-GPX4 activity, triggering ferroptosis in cancer cells and demonstrating better selectivity and safety than existing GPX4 inhibitors, paving the way for new cancer treatments.
Hyperuricemia is mainly caused by insufficient renal urate excretion. Urate transporter 1 (URAT1), an organic anion transporter, is the main protein responsible for urate reabsorption. In this study, we utilized artificial intelligence-based AlphaFold2 program to construct URAT1 structural model.
View Article and Find Full Text PDFVirtual screening of natural products targeting ubiquitin-specific protease 7.
J Biomol Struct Dyn
February 2024
Ubiquitin-specific protease 7 (USP7) is a promising prognostic and druggable target for cancer therapy. Inhibition of USP7 can activate the MDM2-P53 signaling pathway, thereby promoting cancer cell apoptosis. This study based on watvina molecular docking of virtual screening method and biological evaluation found the new USP7 inhibitors targeting catalytic active site.
View Article and Find Full Text PDFObesity-induced lipid metabolism disorders are risk factors for hyperlipidemia, atherosclerosis, and non-alcoholic fatty liver disease. Seaweed oligosaccharides and Zn supplements are potential alternatives to alleviate obesity. Herein, ulvan oligosaccharide (UO) was used as a ligand to prepare a novel Zn supplement (UO-Zn).
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