Publications by authors named "Aouatef Tabbi"
Article Synopsis
- In this study, new thiazole derivatives were created and tested for their anticancer effects on different cancer cell lines (MCF-7, A549, and NIH/3T3) using techniques like the MTT method and flow cytometry.
- One specific compound with a 4-methoxyphenyl group showed the most significant anti-tumor effect against the MCF-7 cell line, indicating high DNA synthesis inhibition and increased apoptosis rates.
- Additionally, compounds with 4-bromo, 4-chloro, and 4-fluorophenyl groups demonstrated strong apoptosis in the A549 cell line at lower concentrations compared to cisplatin, and one compound also exhibited notable anticholinesterase activity with
A new series of -pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The newly synthesized compounds - specifically inhibited monoamine oxidases, displaying notably low IC values.
View Article and Find Full Text PDFBackground: A new variety of adamantyl chalcones (2, 3a-o) were efficiently prepared by Claisen-Schmidt reaction of 4-adamantyl acetophenone 2 with a serie of aromatic aldehydes in good yields. Their structures were confirmed by spectroscopic data, and the relative configuration of 3d was confirmed by X-ray crystallography. All synthesized chalcones were tested against a panel of Grampositive and Gram-negative bacteria and pathogenic fungus and displayed strong antibacterial activity against Enterococcus faecali 29212, Pseudomonas aeruginosa ATCC27853, Escherichia coli and interesting antifungal activity against Candida glabrata ATCC 90030.
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