PsyRiskMR: a comprehensive resource for identifying psychiatric disorders risk factors through Mendelian randomization.

Background: Psychiatric disorders pose an enormous economic and emotional burden on individuals, their families and society. Given that the current analysis of the pathogenesis of psychiatric disorders remains challenging and time-consuming, elucidating the modifiable risk factors becomes crucial for the diagnosis and management of psychiatric disorders. However, inferring the causal risk factors in these disorders from disparate data sources is challenging due to constraints in data collection and analytical capabilities.

Mendelian Randomization Using the Druggable Genome Reveals Genetically Supported Drug Targets for Psychiatric Disorders.

Background And Hypothesis: Psychiatric disorders impose a huge health and economic burden on modern society. However, there is currently no proven completely effective treatment available, partly owing to the inefficiency of drug target identification and validation. We aim to identify therapeutic targets relevant to psychiatric disorders by conducting Mendelian randomization (MR) analysis.