Genetically predicted levels of folate, vitamin B, and risk of autoimmune diseases: A Mendelian randomization study.

Background: Evidence from observational studies on the association of folate and vitamin B with autoimmune diseases are conflicting.

Objective: We aimed to investigate the relationship of folate and vitamin B with autoimmune diseases using Mendelian randomization (MR).

Materials And Methods: We selected single-nucleotide polymorphisms associated with folate and vitamin B at the genome-wide significance level.

Genetically Predicted Circulating Levels of Cytokines and the Risk of Cancer.

Background: Inflammation plays a pivotal role in the pathogenesis of cancer. Though previous studies have reported a link between several inflammatory biomarkers and risk of certain types of cancer, there is a lack of systematic investigation. Therefore, we aimed to assess the role of circulating cytokines on the risk of cancer using a two-sample Mendelian randomization (MR) approach.

Genetically Predicted Serum Albumin and Risk of Colorectal Cancer: A Bidirectional Mendelian Randomization Study.

Purpose: Colorectal cancer (CRC) is the third-most frequently diagnosed cancer globally. Studies have linked low serum albumin with increased risk of CRC, but the causal nature of the association remains unclear. In the present study, we explored the potential causal relationship using bidirectional Mendelian randomization (MR).