Publications by authors named "Aoisha Hoyle"
Article Synopsis
- High-grade serous ovarian carcinoma (HGSOC) has a poor prognosis and is linked to significant chromosome instability (CIN), making it a challenging cancer to treat.
- This study examined 287 HGSOC tissue samples and 73 cell line models, revealing that centrosome amplification (CA) through centriole overduplication is a common and variable characteristic of HGSOC.
- High levels of CA in ovarian cancer cell lines correlate with increased resistance to treatments, especially paclitaxel, suggesting that CA may drive tumor evolution and serve as a valuable biomarker for treatment response.
Objective: Emergency interim guidance from the British Society for Gastroenterology (BSG) states that a no-biopsy strategy is possible to diagnose coeliac disease (CD) in adults with elevated transglutaminase IgA antibody (TGA-IgA) levels. We aimed to determine if the suggested TGA-IgA ≥10× ULN is safe and robust in making the diagnosis in adult patients in Scotland. We also aimed to establish if any important co-diagnoses would be missed if no biopsy was performed.
View Article and Find Full Text PDFIt is now well established that tumours undergo changes in cellular metabolism. As this can reveal tumour cell vulnerabilities and because many tumours exhibit enhanced glucose uptake, we have been interested in how tumour cells respond to different forms of sugar. Here we report that the monosaccharide mannose causes growth retardation in several tumour types in vitro, and enhances cell death in response to major forms of chemotherapy.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the complicated genomic changes in high-grade serous ovarian cancer (HGSOC) and develops a method to identify distinct copy number signatures from the DNA of affected patients.
- Researchers analyzed data from 117 HGSOC cases and validated their findings on 527 additional cases, revealing that HGSOC shows a range of genomic profiles influenced by various genetic mutations.
- These copy number signatures can predict patient survival rates and the risk of treatment resistance, offering a basis for more personalized and effective treatment strategies.
Low-grade spiradenocarcinoma is a rare skin tumor, with fewer than six reported cases, arising in the context of CYLD cutaneous syndrome (CCS; syn: Brooke-Spiegler syndrome [BSS]). We report two independent cases of spiradenocarcinoma arising in a 50-year-old man with CCS. The tumors grew rapidly, prompting clinical excision.
View Article and Find Full Text PDFThe secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome of human mammary normal and cancer-associated fibroblasts (CAFs). We discover that the chloride intracellular channel protein 3 (CLIC3) is an abundant component of the CAF secretome.
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