Publications by authors named "Aoife B Bergin"
Article Synopsis
- PARP-2 is a poly(ADP-ribose) polymerase with activities somewhat like PARP-1 but serves distinct purposes; researchers designed and tested selective inhibitors targeting PARP-2 using isoquinolin-1-one compounds.
- A new method was developed to synthesize 5-aminoisoquinolin-1-one, which was then modified through acylation and other chemical processes to create variants for testing.
- Among the tested compounds, 5-benzamidoisoquinolin-1-one showed the highest selectivity for PARP-2, indicating its potential as a valuable inhibitor, with a comparative selectivity ratio significantly favoring PARP-2 over PARP-1.
