Publications by authors named "Aoi Yamashiro"
Article Synopsis
- The rising global incidence of diabetes raises concerns about chronic health issues, with diabetic nephropathy (DN) being a major cause of kidney failure.
- Podocyte injury in the glomerulus is a key factor in the development of DN, and research shows an increase in phosphorylated ERK (pERK), an active signaling molecule, in patients with DN.
- An immunohistochemical study revealed that podocytes in DN patients exhibit significantly higher pERK levels compared to healthy controls, indicating that ERK activation in podocytes may contribute to DN progression.
Article Synopsis
- A percutaneous kidney biopsy (PKB) is important for treating kidney diseases but has a risk of bleeding complications, which are influenced by factors like urinary N-acetyl-β-D-glucosaminidase (NAG) levels.
- In a study of 213 patients, about 25% experienced significant hemoglobin loss after undergoing PKB, and higher urinary NAG/Cr levels were linked to an increased risk of bleeding events.
- The study suggests that urinary NAG/Cr can predict not only the severity of kidney disease but also potential bleeding risks during and after the biopsy procedure.
Objectives: Several therapeutic agents have been developed and used for the clinical treatment of systemic lupus erythematosus (SLE). In cases where SLE is accompanied by severe organ failures, such as neuropsychiatric lupus erythematosus (NPSLE) and acute onset of lupus nephritis, the use of potent immunosuppressive drugs, such as cyclophosphamide, is necessary. However, potent immunosuppressive drugs are known to increase infection risks.
View Article and Find Full Text PDFHypertension is well-known to often coexist with diabetes mellitus (DM) in humans. Treatment with sodium-glucose cotransporter 2 (SGLT2) inhibitors has been shown to decrease both the blood glucose and the blood pressure (BP) in such patients. Some reports show that SGLT2 inhibitors improve the BP by decreasing the activities of the sympathetic nervous system.
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- A 76-year-old woman presented with anasarca, fever, thrombocytopenia, reticulin fibrosis, and acute kidney injury, leading to the diagnosis of TAFRO syndrome.
- Initial treatments included renal replacement therapy and steroids; however, as her kidney function improved, she developed nephrotic syndrome.
- A kidney biopsy revealed significant macrophage infiltration and a condition resembling membranoproliferative glomerulonephritis, indicating the complexity of kidney dysfunction in TAFRO syndrome, though its underlying mechanisms remain unclear.
A 46-year-old woman suddenly developed peripheral edema. Her massive proteinuria, hypoproteinemia, and renal biopsy findings yielded the diagnosis of minimal change disease (MCD). In addition, lung Mycobacterium avium infection was diagnosed according to a positive culture of her bronchoalveolar lavage fluid.
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