Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Stroke among Patients with Hypertension.

Background: Dysregulations of and were found to be related to lipid metabolism abnormality, which had been proven to be one of the mechanisms of stroke. However, limited epidemiological studies explore the associations between and and the risk of stroke among patients with hypertension in China.

Aims: We aimed to investigate the associations between genetic variants in and and the risk of stroke among patients with hypertension, as well as to explore gene-gene and gene-environment interactions.

Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus.

Objectives: AQP7 and AQP9 represent glycerol channel in adipose tissue and liver and have been associated with metabolic diseases. We aimed to investigate the associations between genetic variants in and genes and the risk of type 2 diabetes (T2DM) in Chinese population.

Methods: Blood samples were drawn from 400 T2DM patients and 400 age- and gender-matched controls.

MALAT1 via microRNA-17 regulation of insulin transcription is involved in the dysfunction of pancreatic β-cells induced by cigarette smoke extract.

Cigarettes contain various chemicals with the potential to influence metabolic health. Exposure to cigarette smoke causes a dysfunction in pancreatic β-cells and impairs insulin production. However, the mechanisms for cigarette smoke-induced reduction of insulin remain largely unclear.

In type 2 diabetes induced by cigarette smoking, activation of p38 MAPK is involved in pancreatic β-cell apoptosis.

Type 2 diabetes (T2D) is a chronic disease caused by pancreatic β-cell dysfunction and insulin resistance. Exposure to smoke is a risk factor for diabetes; however, its mechanisms are unclear. In an epidemiological study, we determined the relationship between cigarette smoking and β-cell function.