Publications by authors named "Aodun Gu"

Article Synopsis
  • Overactive bladder (OAB) is common but has limited treatment options due to issues like side effects and poor effectiveness; targeted drug delivery systems may offer better solutions.* -
  • Researchers tested a new method using polydopamine-coated lactobacillus nanoparticles to deliver the drug solifenacin directly to the bladder, showing good distribution and penetration in lab models.* -
  • The study found that lactobacillus nanoparticles not only reached bladder tissues effectively but also improved treatment outcomes for OAB, suggesting a promising new approach to therapy.*
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Article Synopsis
  • PLK1 is a key regulator impacting the contraction of bladder smooth muscle cells and cellular growth, with its precise role in the lower urinary tract not yet fully understood.
  • Inhibition of PLK1 using the inhibitor TAK-960 significantly reduces muscle contractions and decreases cell viability in human bladder tissues, indicating its importance in bladder function.
  • These findings suggest that targeting PLK1 could lead to new therapeutic strategies for addressing urinary disorders related to abnormal contraction and cell growth.
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