Publications by authors named "Aodun Gu"
Int J Nanomedicine
August 2024
Article Synopsis
- Overactive bladder (OAB) is common but has limited treatment options due to issues like side effects and poor effectiveness; targeted drug delivery systems may offer better solutions.*
-
- Researchers tested a new method using polydopamine-coated lactobacillus nanoparticles to deliver the drug solifenacin directly to the bladder, showing good distribution and penetration in lab models.*
-
- The study found that lactobacillus nanoparticles not only reached bladder tissues effectively but also improved treatment outcomes for OAB, suggesting a promising new approach to therapy.*
Cytoskeleton (Hoboken)
January 2025
Article Synopsis
- PLK1 is a key regulator impacting the contraction of bladder smooth muscle cells and cellular growth, with its precise role in the lower urinary tract not yet fully understood.
- Inhibition of PLK1 using the inhibitor TAK-960 significantly reduces muscle contractions and decreases cell viability in human bladder tissues, indicating its importance in bladder function.
- These findings suggest that targeting PLK1 could lead to new therapeutic strategies for addressing urinary disorders related to abnormal contraction and cell growth.
