Publications by authors named "Ao-Yuan Zhang"
Article Synopsis
- Myocardial ischemia-reperfusion injury (MIRI) is caused by restoring blood flow to heart tissue, leading to issues like oxidative stress and inflammation.
- This study explores the effects of stachyose, a natural compound, on MIRI, finding that it improves heart function and reduces damage in models of the condition.
- Stachyose works by enhancing protective pathways in heart cells and suppressing inflammatory responses in immune cells, suggesting it could be a promising treatment option for MIRI that needs further research.
Background: Sepsis often leads to significant morbidity and mortality due to severe myocardial injury. As is known, the activation of NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome crucially contributes to septic cardiomyopathy (SCM) by facilitating the secretion of interleukin (IL)-1β and IL-18. The removal of palmitoyl groups from NLRP3 is a crucial step in the activation of the NLRP3 inflammasome.
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