Publications by authors named "Ao-Jia Zhou"
Article Synopsis
- NAD levels decrease with age, and supplementing with nicotinamide mononucleotide (NMN), a precursor to NAD, could potentially improve health and longevity in mice on a high-fat diet.
- Long-term NMN treatment resulted in increased NAD levels, reduced obesity, enhanced physical activity, and improved functions of skeletal muscle and kidneys, while also mitigating age-related inflammation.
- The study suggests NMN may protect against diet-induced damage by affecting the autophagic pathway and regulating autophagy levels in different tissues.
Article Synopsis
- Nicotinamide Mononucleotide (NMN) is being researched for its potential anti-aging benefits, particularly regarding muscle and liver functions in middle-aged and elderly people.
- A meta-analysis of randomized controlled trials evaluated the effects of NMN, finding significant improvements in muscle mass and liver enzyme levels among participants.
- The study concludes that NMN shows promise as an effective treatment to enhance muscle function, lower insulin resistance, and improve liver health in older adults.
Background: The beneficial effects of nicotinamide mononucleotide (NMN) on heart disease have been reported, but the effects of NMN on high-fat diet-induced hypertrophic cardiomyopathy (HCM) and its mechanisms of action are unclear. In this study, we systematically explored the effects and mechanism of action of NMN in HCM using network pharmacology and molecular docking.
Methods: Active targets of NMN were obtained from SWISS, CNKI, PubMed, DrugBank, BingingDB, and ZINC databases.
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, with clinical manifestations of resting tremor, akinesia (or bradykinesia), rigidity, and postural instability. However, the molecular pathogenesis of PD is still unclear, and its effective treatments are limited. Substantial evidence demonstrates that long non-coding RNAs (lncRNAs) have important functions in various human diseases, such as cancer, cardiovascular disease, and neurodegenerative diseases.
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