Publications by authors named "Ao-Hui Liu"
Article Synopsis
- Histone H3 Lys36 (H3K36) methylation, particularly H3K36 dimethylation (H3K36me2) and trimethylation (H3K36me3), plays significant roles in DNA double-strand break (DSB) repair through two pathways: non-homologous end joining (NHEJ) and homologous recombination (HR).
- Yeast cells lacking either H3K36me2 or H3K36me3 show reduced efficiency in DSB repair, with proteins yKu70 and Rfa1 interacting with these methylation forms to facilitate the repair process.
- These findings indicate that different forms of H3K36 methylation are essential for
Loss of transcription-coupled histone H3 lysine 36 trimethylation (H3K36me3) contributes to shorter lifespans in eukaryotes. However, the molecular mechanism of the decline of H3K36me3 during aging remains poorly understood. Here, we report that the degradation of the methyltransferase Set2 is the cause of decreased H3K36me3 levels during chronological aging in budding yeast.
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