sVEGFR3 alleviates myocardial ischemia/reperfusion injury through regulating mitochondrial homeostasis and immune cell infiltration.

Recent studies have suggested that sVEGFR3 is involved in cardiac diseases by regulating lymphangiogenesis; however, results are inconsistent. The aim of this study was to investigate the function and mechanism of sVEGFR3 in myocardial ischemia/reperfusion injury (MI/RI). sVEGFR3 effects were evaluated in vivo in mice subjected to MI/RI, and in vitro using HL-1 cells exposed to oxygen-glucose deprivation/reperfusion.

A Microfabrication Technique for High-Performance Diffractive Optical Elements Tailored for Numerical Simulation.

Diffractive optical elements (DOEs) are specialized optical components that manipulate light through diffraction for various applications, including holography, spectroscopy, augmented reality (AR) and virtual reality (VR), and light detection and ranging (LiDAR). The performance of DOEs is highly determined by fabricated materials and fabrication methods, in addition to the numerical simulation design. This paper presents a microfabrication technique optimized for DOEs, enabling precise control of critical parameters, such as refractive index (RI) and thickness.

Polydopamine-Induced BMP7-Poly (Lactic-Co-Glycolic Acid)-Nanoparticle Coating Facilitates Osteogenesis in Porous Tantalum Scaffolds.

Bone defects are difficult to treat clinically and most often require bone grafting for repair. However, the source of autograft bone is limited, and allograft bone carries the risk of disease transmission and immune rejection. As tissue engineering technology advances, bone replacement materials are playing an increasingly important role in the treatment of bone defects.

Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis.

Rheumatoid arthritis (RA), a long-term autoinflammatory condition causing joint damage and deformities, involves a multifaceted pathogenesis with genetic, epigenetic, and immune factors, including early immune aging. However, its precise cause remains elusive. Cellular senescence, a hallmark of aging marked by a permanent halt in cell division due to damage and stress, is crucial in aging and related diseases.

Fluid volume status detection model for patients with heart failure based on machine learning methods.

Backgroud: Fluid volume abnormalities are a major cause of exacerbations in heart failure patients. However, there is few efficient, rapid, or cost-effective clinical approach for determining volume status, resulting in inadequate or unsatisfactory treatment. The aim was to develop an early fluid volume detection model for heart failure patients utilizing a machine learning stratification.

Impact of comprehensive thermal insulation on stress response and immune function in hysteroscopy patients: A retrospective study.

This retrospective study explores the impact of comprehensive thermal insulation measures on the stress response of patients undergoing hysteroscopy surgery. A total of 600 patients who underwent hysteroscopy at our hospital from January 2018 to December 2022 were included. Participants were randomly assigned to an observation group (n = 305) and a control group (n = 295).

Pt ( = 1, 3, and 4) Cluster-Modified MoSe Nanosheets: A Potential Sensing and Scavenging Candidate for Lithium-Ion Battery State Characteristic Gases.

Realizing reliable online detection of characteristic gases (H, CH, CO, and CO) in lithium-ion batteries is crucial to maintain the safe and stable operation of power equipment and new energy storage power plants. In this study, transition metal Pt ( = 1, 3, and 4) clusters are attached to MoSe nanosheets for the first time based on density functional theory using the perfect crystalline facet modification method, and the adsorption characteristics and electronic behaviors of H, CH, CO, and CO are investigated and enhanced. The results show that Pt ( = 1, 3, and 4) is reliably chemically connected to the substrate without any significant deformation of the geometry.

Cooperative Anion-π Catalysis with Chiral Molecular Cages toward Enantioselective Desymmetrization of Anhydrides.

Exploiting novel noncovalent interactions for catalysis design represents a fascinating direction. For the flexible and relatively weak anion-π interactions, manipulation of two or more π-acidic surfaces for cooperative activation is highly desirable. Here, we demonstrate the strategy of cooperative anion-π catalysis based on chiral molecular cages with V-shaped electron-deficient cavities for synergic binding and activation of dicarbonyl electrophiles toward highly enantioselective desymmetrization transformation.

Creep model of bond-degradation in deep granite based on variable radius particle clump.

The creep failure of rocks is related to its microstructure, external loading and time. A nonlinear yield model was introduced to describe the variation in the cohesion and friction angle with plastic strain and intergranular stress. The mechanical properties and creep characteristics of deep granite were obtained by indoor tests, and a variable radius particle clump model was constructed based on the particle flow method.

Effect of knee extension constraint training on walking biomechanics 6 months after anterior cruciate ligament reconstruction: a double-blind randomized controlled clinical trial.

Background: The incidence of knee osteoarthritis after anterior cruciate ligament reconstruction (ACLR) is high to 57%, and the biomechanical abnormality during walking is one of the reasons. The purpose of this study was to investigate the effect of 12 weeks of knee extension constraint training on walking biomechanics during the stance phase of injured side after ACLR.

Methods: Forty-five patients were randomly assigned to three groups based on different brace conditions from 13 weeks to 24 weeks after ACLR: experimental (brace with knee extension constraint), placebo (brace without knee extension constraint), and control (no brace).

A global analysis of dairy consumption and incident cardiovascular disease.

The role of dairy products in cardiovascular disease (CVD) prevention remains controversial. This study investigates the association between dairy consumption and CVD incidence using data from the China Kadoorie Biobank and the UK Biobank, complemented by an updated meta-analysis. Among Chinese participants, regular dairy consumption (primarily whole milk) is associated with a 9% increased risk of coronary heart disease (CHD) and a 6% reduced risk of stroke compared to non-consumers.

Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer.

Inflammation can influence the development of CRC as well as immunotherapy and plays a key role in CRC. Therefore, this study aimed to investigate the potential of inflammation-related genes in CRC risk prediction. Inflammation gene models were constructed and validated by combining transcriptomic and single-cell data from TCGA and GEO databases, and the expression of inflammation-related genes was verified by RT-qPCR.

All-polymer piezo-ionic-electric electronics.

Piezoelectric electronics possess great potential in flexible sensing and energy harvesting applications. However, they suffer from low electromechanical performance in all-organic piezoelectric systems due to the disordered and weakly-polarized interfaces. Here, we demonstrated an all-polymer piezo-ionic-electric electronics with PVDF/Nafion/PVDF (polyvinylidene difluoride) sandwich structure and regularized ion-electron interfaces.

Vascular Smooth Muscle Cells Transdifferentiate into Chondrocyte-Like Cells and Facilitate Meniscal Fibrocartilage Regeneration.

The effective and translational strategy to regenerate knee meniscal fibrocartilage remained challenging. Herein, we first identified vascular smooth muscle cells (VSMCs) transdifferentiated into fibrochondrocytes and participated in spontaneous meniscal regeneration using smooth muscle cell lineage tracing transgenic mice meniscal defect model. Then, we identified low-intensity pulsed ultrasound (LIPUS) acoustic stimulus enhanced fibrochondrogenic transdifferentiation of VSMCs in vitro and in vivo.

Genetic Analysis and Fine Mapping of QTLs for Stigma Exsertion Rate in Rice.

Stigma exsertion rate (SER) is a crucial trait that influences the seed production of hybrid rice by determining the outcrossing ability of male sterile lines (MSLs). However, the molecular genetic mechanisms underlying SER are still poorly understood. In this study, we identified 14 quantitative trait loci (QTLs) using a recombinant inbred line (RIL) population derived from B805D-MR-16-8-3 (B805D) and Hua6S.

Postoperative femoral head cartilage injury after hip arthroscopic treatment for femoroacetabular impingement syndrome and labral tear.

Background: Postoperative femoral head cartilage injury (FHCI) is a rare condition that can be observed in a certain proportion of patients undergoing hip arthroscopy. However, the prevalence and associated factors of FHCI, and the effect of this condition on clinical outcomes still remain unknown.

Patients And Methods: Consecutive patients who were diagnosed with femoroacetabular impingement syndrome (FAIS) and labral tear and underwent hip arthroscopic treatment in our institute between July 2020 and July 2021 were retrospectively evaluated.

High-Efficiency Gold Nanoaggregates for NIR LED-Driven Sustained Mild Photothermal Therapy Achieving Complete Tumor Eradication and Immune Enhancement.

For millennia, humans have harnessed thermal energy to treat cancer. However, delivering energy to tumor tissues in traditional hyperthermia remains a significant challenge. Nanotechnology has revolutionized this approach, enabling nanomaterials to target tumors precisely and act as internal heat sources.

Differential thresholds of net ecosystem productivity in karst and non-karst regions for identifying their potential carbon sinks areas.

Within ecosystems, habitat influences structure, and structure determines function, forming a habitat-structure-function framework (HSFF). Net ecosystem productivity (NEP) is a key indicator for assessing regional or global carbon dynamics. However, the response thresholds of NEP to habitat and structural factors, along with management strategies based on these thresholds, remain under-explored.

Assessing the gap: Resource efficiency of institutionalised elderly care in urban and rural China.

Objectives: The allocation of resources in elderly care institutions is directly linked to the well-being, quality of life and sustainable development of public health for the elderly. However, a disparity in elderly care resources between urban and rural areas exists. Therefore, this study aimed to explore resource allocation efficiency in China's urban and rural institutional elderly care.

Ellagic acid-based non-isocyanate polyurethane water-soluble sizing agents for enhancing the interfacial properties of carbon fiber/epoxy composites.

The preparation of environmentally friendly and efficient waterborne polyurethane sizing agents for carbon fiber (CF) is difficult, especially to avoid the use of isocyanates. Herein, ellagic acid and CO were used to prepare a five-membered cyclic carbonate compound (EARBO). The polymerization between EARBO and diamines enabled the preparation of highly efficient and green aqueous non-isocyanate polyurethane (WNIPU) sizing agents.

Hemophagocytic lymphohistiocytosis caused by multiple infections during primary chemotherapy for pediatric acute lymphoblastic leukemia: a case report.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory disorder that occurs as a consequence of immune dysregulation. HLH can be primary (familial or non-familial) or secondary to infection, autoimmune disease or malignancy. Malignancy-associated HLH is often accompanied by hematologic and lymphoid neoplasms.

[Effect of "Xingshen-Jieyu" electroacupuncture on serum differential metabolites in patients with depression based on metabolomics].

Objectives: To explore the effect of "Xingshen-Jieyu" (inducing resuscitation and dispel ling melancholy) electroacupuncture (EA) on serum metabolites in patients with depression and its underlying mechanisms through serum non-targeted metabolomics.

Methods: Fifteen depression patients were subjected into the EA group, and 15 healthy volunteers were matched into the healthy group. EA (2 Hz/15 Hz, a tolerable strength) was applied to Baihui (GV20), Shenting (GV24), Toulinqi (GB15), Benshen (GB13), Touwei (ST8), Xuanli (GB6) and Qubin (GB7) for 30 min, 3 times a week for 6 weeks.

Lymph Node Metastasis Prediction From In Situ Lung Squamous Cell Carcinoma Histopathology Images Using Deep Learning.

Lung squamous cell carcinoma (LUSC), a subtype of non-small cell lung cancer, represents a significant portion of lung cancer cases with distinct histologic patterns impacting prognosis and treatment. The current pathological assessment methods face limitations such as interobserver variability, necessitating more reliable techniques. This study seeks to predict lymph node metastasis in LUSC using deep learning models applied to histopathology images of primary tumors, offering a more accurate and objective method for diagnosis and prognosis.