Publications by authors named "Ao Mei Zhang"
Article Synopsis
- Social isolation in mice over a period of 8 weeks led to depressive and anxiety-like behaviors, cognitive impairment, and decreased levels of m6A modifications in the hippocampus, along with reduced expression of the enzyme METTL14.
- The study quantified m6A levels and analyzed the effects of over-expressing METTL14 using a viral tool, which showed that restoring METTL14 levels improved mood and cognitive functions in socially isolated mice.
- These findings suggest that m6A modifications and the enzyme METTL14 play a critical role in addressing social isolation-induced behavioral impairments, indicating potential targets for therapeutic strategies in managing related mental health issues.
Stressful life event is closely associated with depression, thus strategies that blunt or prevent the negative effect stress on the brain might benefits for the treatment of depression. Although previous study showed the role of protein kinase R (PKR)-like ER kinase (PERK) in inflammation related depression, its involvement in the neuropathology of chronic stress induced depression is still unknown. We tried to explore whether block the PERK pathway would alleviate the animals' depression-like behavior induced by chronic restraint stress (CRS) and investigate the underlying mechanism.
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