Assembly of Matryoshka-Type Protein Nanocages for Compartmentalized Oxygen Sensing.

Oxygen permeability is a critical property of protein nanocages (PNCs) that impacts or dictates the functions of PNCs. However, it remains challenging to determine it experimentally. Here, we report compartmentalized oxygen sensing inside PNCs by assembling matryoshka-type structures through interfacial engineering, namely, one PNC containing another smaller one functionalized with small-molecule oxygen probes.

Comparative analysis between genotypes of adenovirus isolates from hospitalized children with acute respiratory tract infections and clinical manifestations in Wuhan, China, from June 2022 to September 2023.

Acute respiratory tract infections (ARTIs) are among the leading causes of morbidity and mortality in children worldwide. Human adenovirus (HAdV) infections are estimated to account for at least 5% of pediatric ARTIs. The circulated genotypes of HAdV and the correlation between genotype and clinical manifestations in Wuhan, China, before and after the complete relaxation of nonpharmaceutical interventions against severe acute respiratory syndrome coronavirus 2, remain unknown.

Synthesis and fabrication of magnetically separable phosphate-modified magnetic chitosan composites for lead(II) selective removal from wastewater.

To address the urgent need for efficient removal of lead-containing wastewater and reduce the risk of toxicity associated with heavy-metal wastewater contamination, materials with high removal rates and easy separation must be developed. Herein, a novel organic-inorganic hybrid material based on phosphorylated magnetic chitosan (MSCP) was synthesized and applied for the selective removal of lead (II) from wastewater. From the characterization and the experimental results can be obtained that the magnetic saturation strength of MSCP reaches 14.

Research and experimental verification of lightweight loader rims.

The safety performance and structural stiffness of a rim, which is the main load-bearing structure of the loader during operation, influence the overall performance, stability, and braking capabilities of the machine. In the industry, researchers are currently pursuing lightweight and high-strength rims as a primary objective. A low weight not only enhances machinery fuel efficiency but also aligns with societal demands for sustainable development, energy conservation, and emission reduction.

Morphological measurements and classification of the navicular bone: a study based on computed tomography imaging.

Objective: The purpose of this study was to present the classification of navicular bones and the anatomical basis for the diagnosis and treatment of navicular fractures of the foot.

Method: 351 computed tomographic (CT) images of the navicular bone were analyzed and classified. The navicular bone's anatomical morphology was measured by three independent researchers in each type.

Effect analysis of medial bracing plate combined with cannulated screw in unstable femoral neck fracture assisted by surgical hip dislocation: a retrospective study.

Background: Unstable femoral neck fractures have a high likelihood of causing severe disruption to the blood supply. This study aimed to assess the therapeutic effect of surgical hip dislocation using a medial support plate combined with cannulated screw fixation for the treatment of unstable femoral neck fractures in young and middle-aged adults.

Methods: We retrospectively analyzed the medical records of 68 young adults who underwent internal fixation of unstable femoral neck fractures.

Electronic Structure Optimization and Proton-Transfer Enhancement on Titanium Oxide-Supported Copper Nanoparticles for Enhanced Nitrogen Recycling from Nitrate-Contaminated Water.

Electrocatalytic reduction of nitrate to NH (NO3RR) on Cu offers sustainable NH production and nitrogen recycling from nitrate-contaminated water. However, Cu affords limited NO3RR activity owing to its unfavorable electronic state and the slow proton transfer on its surface, especially in neutral/alkaline media. Furthermore, although a synchronous "NO3RR and NH collection" system has been developed for nitrogen recycling from nitrate-laden water, no system is designed for natural water that generally contains low-concentration nitrate.

Effects of Individual Amino Acids on the Blood Circulation of Biosynthetic Protein Nanocages: Toward Guidance on Surface Engineering.

Protein nanocages (PNCs) hold great promise for developing multifunctional nanomedicines. Long blood circulation is a key requirement of PNCs for most in vivo application scenarios. In addition to the classical PEGylation strategy, short peptides with a specific sequence screened via phage display are also very effective in prolonging the blood half-life (t ) of PNCs.

Electrocatalytic hydrodechlorination system with antiscaling and anti-chlorine poisoning features for salt-laden wastewater treatment.

The high salinity and coexistence of scaling ions (Ca, Mg, HCO) in wastewater challenge the efficacy and durability of palladium (Pd)-mediated electrocatalytic hydrodechlorination (EHDC) reaction for chlorinated organic pollutant detoxification, due to the accompanying Cl poisoning at Pd sites and scaling on electrode. In a concentrated NaCl solution (5.8 g L  ) with Ca (80.

Probing cell membrane integrity using a histone-targeting protein nanocage displaying precisely positioned fluorophores.

Unlabelled: Cell membrane integrity is fundamental to the normal activities of cells and is involved in both acute and chronic pathologies. Here, we report a probe for analyzing cell membrane integrity developed from a 9 nm-sized protein nanocage named Dps via fluorophore conjugation with high spatial precision to avoid self-quenching. The probe cannot enter normal live cells but can accumulate in dead or live cells with damaged membranes, which, interestingly, leads to weak cytoplasmic and strong nuclear staining.

Sedimentary phosphorus fractions in typical lacustrine wetland of Changshou Lake flowing into the Three-Gorges Reservoir.

River damming is ubiquitous which would impact the nutrient cycles of the river systems. Here an early eutrophicated reservoir (Changshou Lake) of the Three Gorges Reservoir (TGR) was selected to investigate the phosphorus (P) biogeochemical migration. Nine sediment cores were collected in the littoral nature lacustrine wetland to help to determine the phosphorus distribution and fraction along the water level.

Passive cancer targeting with a viral nanoparticle depends on the stage of tumorigenesis.

Tumor targeting with nanoparticles is a promising strategy for cancer diagnosis and treatment, especially for drug delivery to solid tumors. Previous studies mainly focused on nanoparticle design to improve their targeting efficiency, but few have investigated the impact of tumor progression stages on the targeting efficiency. Here, we used PEGylated viral nanoparticles (VNPs) of bacteriophage P22 to explore the relationship between targeting efficiency and tumor progression stages using a colorectal cancer model.

A ROS scavenging protein nanocage for and antioxidant treatment.

Elevated levels of reactive oxygen species (ROS) are implicated in the onset and progression of many diseases, e.g., virus infection, ischemic stroke and neurodegenerative diseases.

The complete chloroplast genome sequence of (Magnoliaceae), a rare ornamental and medical tree endemic to China.

is a rare, famous ornamental and important medical tree endemic to China. Here, we assembled the complete chloroplast (cp) genome sequence of . Its length is 159,715 bp with four sub-regions: 87,906 bp of large single-copy region and 18,761 bp of small single-copy region are separated by two inverted repeats regions, each 26,524 bp.

The efficacy and safety of sulindac for colorectal polyps: A protocol for systematic review and meta-analysis.

Background: Sulindac has been used for treating colorectal polyps widely. However, the efficacy and safety of sulindac for colorectal polyps are unclear. This study aims to evaluate the efficacy and safety of sulindac for colorectal polyps.

Role of Surface RGD Patterns on Protein Nanocages in Tumor Targeting Revealed Using Precise Discrete Models.

The effectiveness of active targeting in cancer nanomedicine is becoming increasingly more debatable. Here, the role of the ligand functionalization patterns (number and distribution) on nanoparticle surfaces in tumor targeting is investigated using a 9 nm sized miniferritin protein nanocage, Dps modified with Arg-Gly-Asp (RGD) ligands whose functionalization patterns are precisely controlled. In vitro and in vivo experiments show that RGD modification endows Dps with tumor targeting capacity no matter what the surface pattern is.

Assessment of pollution and identification of sources of heavy metals in the sediments of Changshou Lake in a branch of the Three Gorges Reservoir.

To assess the heavy metal pollution in Changshou Lake, sediments were collected from nine sites at three periods (dry, normal, and wet) in 2013. The Hg, As, Cr, Cd, Pb, Cu, and Zn levels were then determined. The index of geoaccumulation (I geo) and the sediment pollution index (SPI) were applied to the sediment assessment, and Pearson's correlation analysis and factor analysis (FA) were performed to identify common pollution sources in the basin.

Characterization of the complete mitochondrial genome of the firefly, Luciola substriata (Coleoptera: Lampyridae).

The firefly, Luciola substriata (Coleoptera: Lampyridae), is an aquatic firefly species, whose larvae inhabit ponds or lakes. Here we present the complete mitochondrial (mt) genome of the firefly (GenBank accession number KP313820) and provide its annotation. This circular genome is 16,248 bp in length and contains 13 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes, and a non-coding AT-rich region.

Application of fish index of biological integrity (FIBI) in the Sanmenxia Wetland with water quality implications.

Long-term changes of fish biotic integrity in the Sanmenxia Wetland, North China, since the 1950s were assessed using the fish index of biological integrity (FIBI). The water and sediment quality was evaluated by the water quality index (WQI) and sediment pollution index (SPI). The results showed that FIBI continuously decreased from 46 to 20 during the past 5 decades, which indicated that the fish community state shifted from fair to very poor conditions, and damming by itself did not affect the fish biotic integrity.

[Sediment risk assessment and heavy metal source analysis in typical country water level fluctuated zone (WLFZ) of the Three Gorges].

Typical country WLFZ in Zhongxian located in the core region of the Three Gorges Reservoir was chosen as research subject in this study. In July 2012, sediment samples of WLFZ were collected after dam water level dropped. Heavy metals were analyzed for sediment potential risk assessment and then applied for sources analysis in this area, which supplied basic data for non-point pollutants control.

[Heavy metals distribution and risk assessment of sediments in the riverine wetland of Sanmenxia Reservoir].

The survey for contents and fractions of heavy metal in sediments of riverine wetland in Sanmenxia Reservoir were carried out. Sediment pollution index was applied to assess the potential ecological risk and mass fraction of heavy metal in surface sediment was conducted for release risk assessment. The results showed that the total concentrations of Cr, Ni, Cu, Zn, Cd and Pb ranged in 25.

Effectiveness of vegetation on phosphorus removal from reclaimed water by a subsurface flow wetland in a coastal area.

This work was conducted to evaluate the effectiveness and influence factors of vegetation on phosphorus (P) removal from reclaimed water in constructed wetlands. Comparisons were conducted between one pilot scale subsurface flow wetland (P-SSFW) and two demonstration subsurface flow wetlands, which were series-wound and named as first subsurface flow wetland (F-SSFW), and second subsurface flow wetland (S-SSFW), respectively. The three wetlands had the same vegetation and substrate, but different pH values, total dissolved solids (TDS) and P loads.

Morphological stable spirobifluorene/oxadiazole hybrids as bipolar host materials for efficient green and red electrophosphorescence.

A series of 9,9'-spirobifluorene/oxadiazole hybrids with various linkages between two components, namely SBF-p-OXD (1), SBF-m-OXD (2), and SBF-o-OXD (3) are designed and synthesized through Suzuki cross-coupling reactions. The incorporation of a rigid and bulky spirobifluorene moiety greatly improves their thermal and morphological stability, with T(d) (decomposition temperature) and T(g) (glass transition temperature) in the ranges of 401-480 degrees C and 136-210 degrees C, respectively. 2 and 3 with meta- and ortho-linkage display higher triplet energy and blue-shifted absorption and emission than their para-linked analogue 1 owing to the decreasing pi-conjugation between the two components.

Multifunctional bipolar triphenylamine/oxadiazole derivatives: highly efficient blue fluorescence, red phosphorescence host and two-color based white OLEDs.

Two simple triphenylamine/oxadiazole derivatives were synthesized and fully characterized; their multifunctionality as highly efficient non-doped blue fluorescence, excellent red phosphorescent host and single-doped two-color based white OLEDs has been demonstrated.